scispace - formally typeset
Open AccessJournal ArticleDOI

The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

Tsuneo Omura, +1 more
- 01 Jul 1964 - 
- Vol. 239, Iss: 7, pp 2370-2378
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
About
This article is published in Journal of Biological Chemistry.The article was published on 1964-07-01 and is currently open access. It has received 11895 citations till now. The article focuses on the topics: Carbon monoxide binding & Microsome.

read more

Citations
More filters
Journal ArticleDOI

The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.

TL;DR: Aryl hydrocarbon hydroxylase from rat liver metabolizes a variety of polycyclic hydrocarbons and is inducible in fetal cell cultures derived from whole hamster, mouse, rat, and chick.
Journal ArticleDOI

Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients

TL;DR: It is concluded that oxidative stress is developed in the liver of NAFLD patients with steatosis and is exacerbated further in patients with Steatohepatitis, which is associated with CYP2E1 induction.
Journal ArticleDOI

Molecular-genetic analysis of plant cytochrome p450-dependent monooxygenases.

TL;DR: This work has shown that the availability of cloned P450 genes has made possible the analysis of P450 gene regulation and will significantly improve the understanding of many metabolic pathways and may permit their manipulation in the near future.
References
More filters
Journal Article

Protein Measurement with the Folin Phenol Reagent

TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI

The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

TL;DR: Evidence is presented which suggests that this enzyme participates in a microsomal elect,ron transport system which does not include cytochrome c and kinetic evidence has been obtained which allows certain conclusions to be drawn concerning the mechanism of catalysis by this enzyme.
Journal ArticleDOI

Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.

TL;DR: The biological role of reduced triphosphopyridine nucleotide (TPNH) and the metabolic pathways of its hydrogen atom and electron appear to be fundamentally different from those of reduced diphosphipyridineucleotide (DPNH).
Related Papers (5)