The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis
Ryan Higgins,Marie-Helene Miquel Kabbaj,Delaney Sherwin,Lauren A. Howell,Alexa Hatcher,Robert J. Tomko,Yanchang Wang +6 more
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TLDR
This work demonstrates that the CDC48/p97 segregase machinery drives the clearance of ubiquitinated model misfolded protein Huntingtin (Htt103QP) and limits its aggregation and highlights a previously unappreciated function for Cdc48 in ensuring the regeneration of monoubiquitin that is critical for normal cellular function.About:
This article is published in Cell Reports.The article was published on 2020-07-14 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Ubiquitin homeostasis & Ubiquitin ligase.read more
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The Cytotoxicity and Clearance of Mutant Huntingtin and Other Misfolded Proteins.
Austin Folger,Yanchang Wang +1 more
TL;DR: A review of the current understanding of the cytotoxicity of misfolded proteins as well as their clearance pathways, with a particular emphasis on mutant Huntingtin, is presented in this article.
Journal ArticleDOI
Mapping the degradation pathway of a disease-linked aspartoacylase variant.
Sarah K. Gersing,Yong Wang,Martin Grønbæk-Thygesen,Caroline Kampmeyer,Lene Clausen,Martin Willemoës,Claes Andréasson,Amelie Stein,Kresten Lindorff-Larsen,Rasmus Hartmann-Petersen +9 more
TL;DR: In this paper, the degradation pathway of a disease-causing protein variant was investigated using ASPA C152W as a model to investigate the de novo folding pathway of the protein degradation pathway.
Journal ArticleDOI
Genetic profiling of protein burden and nuclear export overload
Reiko Kintaka,Koji Makanae,Shotaro Namba,Hisaaki Kato,Keiji Kito,Shinsuke Ohnuki,Yoshikazu Ohya,Brenda J. Andrews,Charles Boone,Hisao Moriya +9 more
TL;DR: The tGFP-op interactions suggested that this protein probe overloads the proteasome, whereas those that interacted with NES-tGFP involved genes encoding components of the nuclear export process, providing a resource for further analysis of the protein burden and nuclear export overload.
Journal ArticleDOI
Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion.
TL;DR: The current knowledge of how Cdc48/p97 regulates mitofusin activity in outer membrane fusion and how this may impact on neurodegeneration is presented and discussed.
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The chaperone-like protein Cdc48 regulates ubiquitin-proteasome system in plants.
Claire Rosnoblet,Pauline Chatelain,Agnès Klinguer,Hervé Bègue,Pascale Winckler,Carole Pichereaux,Carole Pichereaux,David Wendehenne +7 more
TL;DR: In this paper, the role of Cdc48 in the regulation of the ubiquitin-proteasome system (UPS) in tobacco cells and leaves was investigated in response to cryptogein.
References
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