Journal ArticleDOI
The control of polycomb repressive complexes by long noncoding RNAs.
Jackson B. Trotman,Keean C.A. Braceros,Rachel E Cherney,McKenzie M. Murvin,J. Mauro Calabrese +4 more
TLDR
The polycomb repressive complexes 1 and 2 (PRCs; PRC1 and PRC2) are conserved histone-modifying enzymes that often function cooperatively to repress gene expression as discussed by the authors.Abstract:
The polycomb repressive complexes 1 and 2 (PRCs; PRC1 and PRC2) are conserved histone-modifying enzymes that often function cooperatively to repress gene expression. The PRCs are regulated by long noncoding RNAs (lncRNAs) in complex ways. On the one hand, specific lncRNAs cause the PRCs to engage with chromatin and repress gene expression over genomic regions that can span megabases. On the other hand, the PRCs bind RNA with seemingly little sequence specificity, and at least in the case of PRC2, direct RNA-binding has the effect of inhibiting the enzyme. Thus, some RNAs appear to promote PRC activity, while others may inhibit it. The reasons behind this apparent dichotomy are unclear. The most potent PRC-activating lncRNAs associate with chromatin and are predominantly unspliced or harbor unusually long exons. Emerging data imply that these lncRNAs promote PRC activity through internal RNA sequence elements that arise and disappear rapidly in evolutionary time. These sequence elements may function by interacting with common subsets of RNA-binding proteins that recruit or stabilize PRCs on chromatin. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.read more
Citations
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Journal ArticleDOI
Long Non-Coding RNA Epigenetics.
TL;DR: In this paper, the most common modified nucleosides found in lncRNA, 6-methyladenosine, 5-methylcytidine, pseudouridine and inosine are described.
Journal ArticleDOI
The Importance of Networking: Plant Polycomb Repressive Complex 2 and Its Interactors
James Godwin,Sara Farrona +1 more
TL;DR: This review presents a list of PRC2 interactors, emphasizing their mechanistic action uponPRC2 functions and their effects on transcriptional regulation.
Journal ArticleDOI
LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression.
Xiaodong Yang,Yi Zhang,Yimeng Chen,Xiaoqin He,Yiwei Qian,Shaoqing Xu,Chao Gao,Chengjun Mo,Sheng-Di Chen,Qin Xiao +9 more
TL;DR: Zhang et al. as mentioned in this paper found that HOXA-AS2 was upregulated in the peripheral blood mononuclear cells (PBMCs) of PD patients and negatively associated with peroxisome proliferator-activated receptor gamma coactivator-1a (PGC-1α) expression.
Journal ArticleDOI
De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses.
TL;DR: In this article, the authors describe how polycomb-mediated silencing potentially assembles onto herpesvirus genomes, synergizing what is known about herpes virus latency with facultative heterochromatin targeting to the cellular genome.
Journal ArticleDOI
Modulation of the high-order chromatin structure by Polycomb complexes
Yiran Guo,Gang Wang +1 more
TL;DR: Current advances as for how Polycomb complexes function to modulate and help define the high-order chromatin structure and topology are reviewed, highlighting the multi-faceted roles of Polycomb proteins in gene and genome regulation.
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