Journal ArticleDOI
The current status of preclinical proton FLASH radiation and future directions.
TLDR
A review of the current status of proton FLASH experimental systems, including preclinical physical and biological results, is provided in this article, where the authors focus on future areas of development with a focus on the determination of the optimal parameters for maximizing the therapeutic ratio between tumor and normal tissue response.Abstract:
We review the current status of proton FLASH experimental systems, including preclinical physical and biological results. Technological limitations on preclinical investigation of FLASH biological mechanisms and determination of clinically relevant parameters are discussed. A review of the biological data reveals no reproduced proton FLASH effect in vitro and a significant in vivo FLASH sparing effect of normal tissue toxicity observed with multiple proton FLASH irradiation systems. Importantly, multiple studies suggest little or no difference in tumor growth delay for proton FLASH when compared to conventional dose rate proton radiation. A discussion follows on future areas of development with a focus on the determination of the optimal parameters for maximizing the therapeutic ratio between tumor and normal tissue response and ultimately clinical translation of proton FLASH radiation.read more
Citations
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Journal ArticleDOI
Tumour irradiation in mice with a laser-accelerated proton beam
Florian Kroll,Florian-Emanuel Brack,Constantin Bernert,Stefan Bock,Elisabeth Bodenstein,Kerstin Brüchner,Thomas E. Cowan,Lennart Gaus,René Gebhardt,U. Helbig,Leonhard Karsch,T. Kluge,Stephan Kraft,Mechthild Krause,Elisabeth Lessmann,U. Masood,Sebastian Meister,Josefine Metzkes-Ng,Alexej Nossula,Jörg Pawelke,J. Pietzsch,Thomas A. Püschel,M Reimold,Martin Rehwald,Christian Richter,Hans-Peter Schlenvoigt,Ulrich Schramm,Marvin Elias Paul Umlandt,Tim Ziegler,K. O. Zell,Elke Beyreuther +30 more
TL;DR: In this article , a stable, compact laser-driven proton source with energies greater than 60 MeV enables radiobiological in vivo studies, and the results demonstrate a complete laser driven proton research platform for diverse user-specific small animal models, able to deliver tunable single shot doses up to around 20 Gy to millimetre-scale volumes on nanosecond timescales.
Journal ArticleDOI
Towards clinical translation of FLASH radiotherapy
TL;DR: An overview of the principles underlying FLASH radiotherapy is provided and the challenges along the path towards its clinical application are discussed, including the need for a better understanding of the biological mechanisms, optimization of parameters and technological challenges.
Journal ArticleDOI
Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo.
Leonhard Karsch,Jörg Pawelke,Michael Brand,Stefan Hans,Katalin Hideghéty,Jeannette Jansen,Elisabeth Lessmann,S. Löck,Michael Schürer,R. Schurig,Joao Seco,Emília Rita Szabó,Elke Beyreuther +12 more
TL;DR: In this article , the effect of beam pulse structure on the Flash effect was investigated at the research electron accelerator ELBE at the Helmholtz-Zentrum Dresden-Rossendorf.
Journal ArticleDOI
A roadmap to clinical trials for FLASH
TL;DR: The state of quality assurance and safety systems in FLASH is reviewed, critical pre‐clinical data points that need to be defined are identified, and lessons learned from previous technological advancements will help to close the gaps and build a successful path to evidence‐driven FLASH implementation are suggested.
Journal ArticleDOI
Comparing radiolytic production of H2O2 and development of Zebrafish embryos after ultra high dose rate exposure with electron and Transmission proton beams.
Houda Haj Kacem,S. Psoroulas,Gael Boivin,Michael Folkerts,Veljko Grilj,T. Lomax,Adrien Martinotti,D. Meer,Jonathan Ollivier,Benoit Petit,Sairos Safai,Ricky A. Sharma,Michele Togno,Marta Vilalta,Damien C. Weber,Marie-Catherine Vozenin +15 more
TL;DR: In this paper , the Physico-chemical and biological response to conventional and UHDR electron and proton beams was investigated, along with conventional photons, and the temporal structure and nature of the beam affected both, with electron beam at ≥ 1400 Gy/s and proion beam at 0.1 and 1260 Gy/m found to be isoefficient at sparing zebrafish embryos.
References
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Journal ArticleDOI
Radiochromic film dosimetry: Recommendations of AAPM Radiation Therapy Committee Task Group 55
Azam Niroomand-Rad,Charles Robert Blackwell,Bert M. Coursey,Kenneth P. Gall,James M. Galvin,William L. McLaughlin,Ali S. Meigooni,Ravinder Nath,James E. Rodgers,Christopher G. Soares +9 more
TL;DR: Recommendations of the American Association of Physicists in Medicine for the radiochromic film dosimetry are presented and have been reviewed and approved by the AAPM Science Council.
Journal ArticleDOI
Exploring the role of cancer stem cells in radioresistance.
TL;DR: This work states that new technologies allow isolation of cells expressing specific surface markers that are differentially expressed in tumour cell subpopulations that are enriched for cancer stem cells, and Combining these techniques with functional radiobiological assays holds the potential to elucidate the role of cancer stem Cells in radioresistance in individual tumours.
Journal ArticleDOI
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
Vincent Favaudon,Vincent Favaudon,Laura Caplier,Virginie Monceau,Virginie Monceau,Frederic Pouzoulet,Frederic Pouzoulet,Mano Sayarath,Mano Sayarath,Charles Fouillade,Charles Fouillade,Marie-France Poupon,Marie-France Poupon,Isabel Brito,Isabel Brito,Philippe Hupé,Jean Bourhis,Jean Bourhis,Jean Bourhis,Janet Hall,Janet Hall,Jean-Jacques Fontaine,Marie-Catherine Vozenin +22 more
TL;DR: The results suggest that FLASH radiation may be a viable option for treating lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
Journal ArticleDOI
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Marie-Catherine Vozenin,Pauline de Fornel,Kristoffer Petersson,Vincent Favaudon,Maud Jaccard,Jean François Germond,Benoit Petit,Marco Burki,Gisele Ferrand,David Patin,Hanan Bouchaab,Mahmut Ozsahin,François Bochud,Claude Bailat,Patrick Devauchelle,Jean Bourhis +15 more
TL;DR: The results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLash-RT in human patients.
Journal ArticleDOI
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s
Pierre Montay-Gruel,Pierre Montay-Gruel,Kristoffer Petersson,Maud Jaccard,Gael Boivin,Jean-François Germond,Benoit Petit,Raphael Doenlen,Vincent Favaudon,François Bochud,Claude Bailat,Jean Bourhis,Marie-Catherine Vozenin +12 more
TL;DR: This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate.