Journal ArticleDOI
The Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study
Jason A. Roberts,Gavin M. Joynt,Anna Lee,Gordon Y.S. Choi,Rinaldo Bellomo,Salmaan Kanji,Salmaan Kanji,M Yugan Mudaliar,Sandra L. Peake,Sandra L. Peake,Dianne P Stephens,Fabio Silvio Taccone,Marta Ulldemolins,Miia Valkonen,Julius Agbeve,João P Baptista,Vasileios Bekos,Clément Boidin,Clément Boidin,Alexander Brinkmann,Luke Buizen,Pedro Castro,C Louise Cole,C Louise Cole,Jacques Creteur,Jan J. De Waele,Renae Deans,Glenn M Eastwood,Leslie Escobar,Charles D. Gomersall,Rebecca Gresham,Janattul Ain Jamal,Stefan Kluge,Christina König,Christina König,Vasilios P Koulouras,Melissa Lassig-Smith,Pierre-François Laterre,Katie Lei,Patricia Leung,Jean-Yves Lefrant,Mireia Llaurado-Serra,Ignacio Martin-Loeches,Mohd Basri Mat Nor,Marlies Ostermann,Suzanne L. Parker,Jordi Rello,Darren M. Roberts,Michael S. Roberts,Michael S. Roberts,Brent Richards,Alejandro Rodríguez,Anka C Roehr,Claire Roger,Leonardo Seoane,Leonardo Seoane,Mahipal G. Sinnollareddy,Eduardo Sousa,Dolors Soy,Anna Spring,Therese Starr,Jane Thomas,John D. Turnidge,Steven C. Wallis,Tricia Williams,Tricia Williams,Xavier Wittebole,Xanthi T Zikou,Sanjoy K. Paul,Jeffrey Lipman,Jeffrey Lipman +70 more
TLDR
In critically ill patients treated with RRT, antibiotic dosing regimens, RRT prescription and eTRCL varied markedly and resulted in highly variable antibiotic concentrations that failed to meet therapeutic targets in many patients.Abstract:
The optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT techniques and antibiotic dosing in critically ill patients receiving RRT and to relate observed trough antibiotic concentrations to optimal targets. We performed a prospective, observational, multi-national, pharmacokinetic study in 29 intensive care units from 14 countries. We collected demographic, clinical and RRT data. We measured trough antibiotic concentrations of meropenem, piperacillin-tazobactam and vancomycin and related them to high and low target trough concentrations. We studied 381 patients and obtained 508 trough antibiotic concentrations. There was wide variability (4-8 fold) in antibiotic dosing regimens; RRT prescription, and estimated endogenous renal function. The overall median estimated total renal clearance (eTRCL) was 50 mL/min (interquartile range [IQR] 35-65) and higher eTRCL was associated with lower trough concentrations for all antibiotics (p In critically ill patients treated with RRT, antibiotic dosing regimens, RRT prescription and eTRCL varied markedly and resulted in highly variable antibiotic concentrations that failed to meet therapeutic targets in many patients.read more
Citations
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Journal ArticleDOI
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
Laura Evans,Andrew Rhodes,Waleed Alhazzani,Massimo Antonelli,Craig M. Coopersmith,Craig French,Flávia Ribeiro Machado,Lauralyn McIntyre,Marlies Ostermann,Hallie C. Prescott,Christa Schorr,Steven Q. Simpson,W. Joost Wiersinga,Fayez Alshamsi,Derek C. Angus,Yaseen M. Arabi,Luciano Cesar Pontes Azevedo,Richard Beale,Gregory J. Beilman,Emilie P. Belley-Côté,Lisa Burry,Maurizio Cecconi,John Centofanti,Angel Coz Yataco,Jan De Waele,R. Phillip Dellinger,Kent Doi,Bin Du,Elisa Estenssoro,Ricard Ferrer,Charles D. Gomersall,Carol L. Hodgson,Morten Hylander Møller,Theodore J. Iwashyna,Shevin T. Jacob,Ruth M. Kleinpell,Michael Klompas,Michael Klompas,Younsuck Koh,Anand Kumar,Arthur Kwizera,Suzana Margareth Lobo,Henry Masur,Steven McGloughlin,Sangeeta Mehta,Yatin Mehta,Mervyn Mer,Mark E. Nunnally,Simon Oczkowski,Tiffany M. Osborn,Elizabeth Papathanassoglou,Anders Perner,Michael A. Puskarich,Jason A. Roberts,William D. Schweickert,Maureen A. Seckel,Jonathan E. Sevransky,Charles L. Sprung,Charles L. Sprung,Tobias Welte,Janice L. Zimmerman,Mitchell M. Levy +61 more
TL;DR: The Surviving Sepsis Campaign (SSC) guidelines provide evidence-based recommendations on the recognition and management of sepsis and its complications as discussed by the authors, which are either strong or weak, or in the form of best practice statements.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Laura Evans,Andrew Rhodes,Waleed Alhazzani,Massimo Antonelli,Craig M. Coopersmith,Craig French,Flávia Ribeiro Machado,Lauralyn McIntyre,Marlies Ostermann,Hallie C. Prescott,Christa Schorr,Steven Q. Simpson,W. Joost Wiersinga,Fayez Alshamsi,Derek C. Angus,Yaseen M. Arabi,Luciano Cesar Pontes Azevedo,Richard Beale,Gregory J. Beilman,Emilie P. Belley-Côté,Lisa Burry,Maurizio Cecconi,John Centofanti,Angel Coz Yataco,Jan De Waele,R. Phillip Dellinger,Kent Doi,Bin Du,Elisa Estenssoro,Ricard Ferrer,Charles D. Gomersall,Carol L. Hodgson,Morten Hylander Møller,Theodore J. Iwashyna,Shevin T. Jacob,Ruth M. Kleinpell,Michael Klompas,Younsuck Koh,Anand Kumar,Arthur Kwizera,Suzana Margareth Lobo,Henry Masur,Steven McGloughlin,Sangeeta Mehta,Yatin Mehta,Mervyn Mer,Mark E. Nunnally,Simon Oczkowski,Tiffany M. Osborn,Elizabeth Papathanassoglou,Anders Perner,Michael A. Puskarich,Jason A. Roberts,William D. Schweickert,Maureen A. Seckel,Jonathan E. Sevransky,Charles L. Sprung,Tobias Welte,Janice L. Zimmerman,Mitchell M. Levy +59 more
TL;DR: The Surviving Sepsis Campaign (SSC) guidelines provide evidence-based recommendations on the recognition and management of sepsis and its complications as mentioned in this paper, which are either strong or weak, or in the form of best practice statements.
Journal ArticleDOI
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper .
Mohd H. Abdul-Aziz,Jan-Willem C. Alffenaar,Jan-Willem C. Alffenaar,Matteo Bassetti,Hendrik Bracht,George Dimopoulos,Deborah Marriott,Michael Neely,Michael Neely,José Artur Paiva,Federico Pea,Fredrik Sjövall,Jean F. Timsit,Jean F. Timsit,Andrew A. Udy,Sebastian G. Wicha,Markus Zeitlinger,Jan J. De Waele,Jason A. Roberts,Pharmacokinetic,pharmacodynamic +20 more
TL;DR: Routine TDM is recommended to be performed for aminoglycosides, beta-lactam antibiotics, linezolid, teicoplanin, vancomycin and voriconazole in critically ill patients.
Journal ArticleDOI
Recommendation of Antimicrobial Dosing Optimization During Continuous Renal Replacement Therapy.
Lu Li,Xin Li,Yanzhe Xia,Yanqi Chu,Hai-Li Zhong,Jia Li,Pei Liang,Yishan Bu,Rui Zhao,Yun Liao,Ping Yang,Xiaoyang Lu,Saiping Jiang +12 more
TL;DR: The literatures involving in new progresses of antimicrobial dosages are reviewed, and the updated empirical dosing strategies based on CRRT modalities and effluent flow rates are complied.
Journal ArticleDOI
Model-Informed Drug Development for Anti-Infectives: State of the Art and Future.
Craig R. Rayner,Craig R. Rayner,Patrick F. Smith,David R. Andes,Kayla Ann Andrews,Hartmut Derendorf,Lena E. Friberg,Debra Hanna,Alex Lepak,Edward J Mills,Thomas M. Polasek,Thomas M. Polasek,Thomas M. Polasek,Jason A. Roberts,Jason A. Roberts,Jason A. Roberts,Virna J A Schuck,Mark J. Shelton,David Wesche,Karen Rowland‐Yeo +19 more
TL;DR: Model-informed drug development (MIDD) has a long and rich history in infectious diseases as discussed by the authors, including the development of antibacterials (review of minimum inhibitory concentration-based models, mechanism-based pharmacokinetic/PD (PK/PD) models, PK/PD models of resistance, and immune response).
References
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Journal ArticleDOI
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock.
Anand Kumar,Daniel Roberts,Kenneth E. Wood,Bruce Light,Joseph E. Parrillo,Satendra Sharma,Robert Suppes,Daniel Feinstein,Sergio Zanotti,Leo Taiberg,David A. Gurka,Aseem Kumar,Mary Cheang +12 more
TL;DR: Effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock.
Journal ArticleDOI
Acute Renal Failure in Critically Ill Patients: A Multinational, Multicenter Study
Shigehiko Uchino,John A. Kellum,Rinaldo Bellomo,Gordon S. Doig,Hiroshi Morimatsu,Stanislao Morgera,Miet Schetz,Ian Tan,Catherine S. C. Bouman,Ettiene Macedo,Noel Gibney,Ashita Tolwani,Claudio Ronco +12 more
TL;DR: In this article, the period prevalence of acute renal failure (ARF) requiring renal replacement therapy (RRT) was found to be between 5% and 6% and was associated with a high hospital mortality rate.
Journal ArticleDOI
Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children
Catherine Liu,Arnold S. Bayer,Sara E. Cosgrove,Robert S. Daum,Scott K. Fridkin,Rachel J. Gorwitz,Sheldon L. Kaplan,Adolf W. Karchmer,Donald P. Levine,Barbara E. Murray,Michael J. Rybak,Henry F. Chambers +11 more
TL;DR: These guidelines discuss the management of a variety of clinical syndromes associated with MRSA disease, including skin and soft tissue infections (SSTI), bacteremia and endocarditis, pneumonia, bone and joint infections, and central nervous system infections.
Journal ArticleDOI
Pharmacokinetic/Pharmacodynamic Parameters: Rationale for Antibacterial Dosing of Mice and Men
TL;DR: The potential value of using pharmacokinetic/pharmacodynamic parameters as guides for establishing optimal dosing regimens for new and old drugs and for new emerging pathogens and resistant organisms should make the continuing search for the therapeutic rationale of antibacterial dosing of mice and men worthwhile.
Journal ArticleDOI
International Study of the Prevalence and Outcomes of Infection in Intensive Care Units
Jean Louis Vincent,Jordi Rello,John C. Marshall,Eliezer Silva,Antonio Anzueto,Claude Martin,Rui Moreno,Jeffrey Lipman,Charles D. Gomersall,Yasser Sakr,Konrad Reinhart +10 more
TL;DR: In this large cohort, infection was independently associated with an increased risk of hospital death and risk of infection increases with duration of ICU stay.
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