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Journal ArticleDOI

The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.

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TLDR
There is an increased percentage of WOI displacement in RIF patients compared with comparison group patients, leading to the concept of pET as a therapeutic strategy.
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This article is published in Fertility and Sterility.The article was published on 2013-09-01. It has received 351 citations till now.

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Posted ContentDOI

PAEP and cilia gene splicing changes in endometrial glands during the implantation window in women with recurrent pregnancy loss

TL;DR: In this paper, an endometrial gland specific transcriptome and splicing profile are altered in women with recurrent pregnancy loss, which can be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy losses and develop targeted therapies in personalised medicine.
Journal ArticleDOI

Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis

TL;DR: In this paper , the authors collected and summarized all information published in the scientific literature to assess the evidence of the platelet-rich plasma (PRP) effect on pregnancy, and only considered randomized controlled trials (RCT), a type of study designed to be unbiased and considered at the highest level of evidence.
Book ChapterDOI

Endometrial receptivity and genetics

Nick Macklon
TL;DR: In this chapter a clinical perspective is given on genetic interrogation of the endometrium in the context of fertility treatments.
Book ChapterDOI

Endometrial Receptivity by Endometrial Receptivity Analysis (ERA) for Infertility

TL;DR: The development of new technologies, such as microarrays and next-generation sequencing, allowed to develop a transcriptomic tool able to identify the endometrial status of each patient in a specific moment, which has allowed a better clinical management of infertility with anendometrial origin.
Book ChapterDOI

The Embryo Day 3 Versus Day 5 ET

TL;DR: All patients undergoing superovulation during IVF are at risk for embryonic-endometrial dysynchrony and success depends on alignment of the endometrial window of receptivity and embryonic window of implantation.
References
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Journal ArticleDOI

Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women

TL;DR: Endometrial samples obtained by two different sampling techniques from subjects who are as normal as possible in a human study and including those with unknown histology, can be classified by their molecular signatures and correspond to known phases of the menstrual cycle with identical results using two independent analytical methods.
Journal ArticleDOI

A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature

TL;DR: A genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies ofendometrial origin can be used clinically in reproductive medicine and gynecology and the transcriptomic signature is a potential endometrian receptivity biomarkers cluster.
Journal ArticleDOI

Investigation and treatment of repeated implantation failure following IVF-ET

TL;DR: The suggested methods for evaluation and treatment of RIF are discussed: repeated hysteroscopy, myomectomy, endometrial stimulation, immunotherapy, preimplantation genetic screening (PGS), assisted hatching, zygote intra-Fallopian transfer (ZIFT), co-culture, blastocyst transfer, cytoplasmic transfer, tailoring stimulation protocols and salpingectomy for hydrosalpinges.
Journal ArticleDOI

Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology

TL;DR: Gene expression profiles of pre-receptive versus receptive endometria obtained from the same fertile woman in the same menstrual cycle are compared to gain a global molecular understanding of human endometrial receptivity.
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