Journal ArticleDOI
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Maria Ruiz-Alonso,David Blesa,Patricia Diaz-Gimeno,Eva Gómez,Manuel Fernández-Sánchez,F. Carranza,Joan Carrera,F. Vilella,Antonio Pellicer,Carlos Simón +9 more
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TLDR
There is an increased percentage of WOI displacement in RIF patients compared with comparison group patients, leading to the concept of pET as a therapeutic strategy.About:
This article is published in Fertility and Sterility.The article was published on 2013-09-01. It has received 351 citations till now.read more
Citations
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Journal ArticleDOI
Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes.
Douglas A Gibson,Ioannis Simitsidellis,Fiona L. Cousins,Hilary O. D. Critchley,Philippa T. K. Saunders +4 more
TL;DR: Intracrine biosynthesis of endometrial androgens during decidualization may play a key role inendometrial receptivity and offer a novel target for fertility treatment.
Journal ArticleDOI
Recurrent implantation failure in IVF: A Canadian Fertility and Andrology Society Clinical Practice Guideline.
TL;DR: This guideline recognizes the presence of heterogeneity in the definition of RIF and recommends options that may increase the chance of a live birth.
Journal ArticleDOI
Endometrial microbiota composition is associated with reproductive outcome in infertile patients
Inmaculada Moreno,Iolanda Garcia-Grau,David Pérez-Villaroya,Marta Gonzalez-Monfort,Mustafa Bahceci,Marcelo J. Barrionuevo,Sagiri Taguchi,Elena Puente,M. DiMattina,Mei Wei Lim,Georgina Meneghini,Mira Aubuchon,M.R. Leondires,Alexandra Izquierdo,Martina Perez-Olgiati,Alejandro Chavez,Kenneth Seethram,Davide Bau,Carlos Gómez,Diana Valbuena,Felipe Vilella,Carlos Simón +21 more
TL;DR: In this article , a multicentre prospective observational study using 16S rRNA gene sequencing to analyse endometrial fluid and biopsy samples before embryo transfer in a cohort of 342 infertile patients undergoing assisted reproductive treatments was presented.
Journal ArticleDOI
Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis.
Andrea Busnelli,Edgardo Somigliana,Federico Cirillo,Annamaria Baggiani,Paolo Emanuele Levi-Setti +4 more
TL;DR: In this article, a systematic review and meta-analysis was conducted to assess the effect of the different therapeutic options for repeated embryo implantation failure (RIF) on a subsequent IVF cycle outcome.
Journal ArticleDOI
Window of implantation transcriptomic stratification reveals different endometrial subsignatures associated with live birth and biochemical pregnancy
Patricia Diaz-Gimeno,Maria Ruiz-Alonso,Patricia Sebastian-Leon,Antonio Pellicer,Antonio Pellicer,Diana Valbuena,Carlos Simón +6 more
TL;DR: The retrospective cohort study identified an optimal endometrial receptivity signature resulting in an ongoing pregnancy rate (OPR) of 80% in terms of live birth and a late receptive-stage signature with a potential high risk of 50% biochemical pregnancy.
References
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Journal ArticleDOI
Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women
Said Talbi,A.E. Hamilton,Kim Chi Vo,Suzana Tulac,Michael Toft Overgaard,Chrysoula Dosiou,N Le Shay,C.N. Nezhat,R Kempson,Bruce A. Lessey,Nihar R. Nayak,Linda C. Giudice +11 more
TL;DR: Endometrial samples obtained by two different sampling techniques from subjects who are as normal as possible in a human study and including those with unknown histology, can be classified by their molecular signatures and correspond to known phases of the menstrual cycle with identical results using two independent analytical methods.
Journal ArticleDOI
A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature
Patricia Diaz-Gimeno,José A. Horcajadas,José Antonio Martínez-Conejero,Francisco J. Esteban,Pilar Alamá,Antonio Pellicer,Carlos Simón +6 more
TL;DR: A genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies ofendometrial origin can be used clinically in reproductive medicine and gynecology and the transcriptomic signature is a potential endometrian receptivity biomarkers cluster.
Journal ArticleDOI
Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization.
TL;DR: It is suggested that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.
Journal ArticleDOI
Investigation and treatment of repeated implantation failure following IVF-ET
TL;DR: The suggested methods for evaluation and treatment of RIF are discussed: repeated hysteroscopy, myomectomy, endometrial stimulation, immunotherapy, preimplantation genetic screening (PGS), assisted hatching, zygote intra-Fallopian transfer (ZIFT), co-culture, blastocyst transfer, cytoplasmic transfer, tailoring stimulation protocols and salpingectomy for hydrosalpinges.
Journal ArticleDOI
Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology
Anne Riesewijk,Julio Martín,Roselinde van Os,José A. Horcajadas,Jan Polman,Antonio Pellicer,Sietse Mosselman,Carlos Simón +7 more
TL;DR: Gene expression profiles of pre-receptive versus receptive endometria obtained from the same fertile woman in the same menstrual cycle are compared to gain a global molecular understanding of human endometrial receptivity.