Journal ArticleDOI
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Maria Ruiz-Alonso,David Blesa,Patricia Diaz-Gimeno,Eva Gómez,Manuel Fernández-Sánchez,F. Carranza,Joan Carrera,F. Vilella,Antonio Pellicer,Carlos Simón +9 more
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TLDR
There is an increased percentage of WOI displacement in RIF patients compared with comparison group patients, leading to the concept of pET as a therapeutic strategy.About:
This article is published in Fertility and Sterility.The article was published on 2013-09-01. It has received 351 citations till now.read more
Citations
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Journal ArticleDOI
Does the endometrial receptivity array really provide personalized embryo transfer
Rawad Bassil,Robert F. Casper,Nivin Samara,Tzu-Bou Hsieh,Eran Barzilay,Raoul Orvieto,Raoul Orvieto,Jigal Haas +7 more
TL;DR: Performing the ERA test in a mock cycle prior to a FET does not seem to improve the ongoing pregnancy rate in good prognosis patients and further large prospective studies are needed to elucidate the role of ERA testing in both good prog outlook patients and in patients with recurrent implantation failure.
Journal ArticleDOI
Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two‐centers study
Tomoko Hashimoto,Masae Koizumi,Masakazu Doshida,Mayumi Toya,Eri Sagara,N. Oka,Yukiko Nakajo,Nobuya Aono,Hideki Igarashi,Koichi Kyono +9 more
TL;DR: This study aimed to assess the efficacy of the endometrial receptivity array (ERA) as a diagnostic tool and the impact of personalized embryo transfer (pET) for the treatment of patients with recurrent implantation failure (RIF) in Japan.
Journal ArticleDOI
The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy.
TL;DR: More research is still needed to better understand abnormal interactions between the embryo and the milieu in artificial conditions, and optimization of the environment will be the key to improving the dialogue between the endometrium and embryo, so as to ensure that placentation after ART is similar to that following natural conception.
Journal ArticleDOI
Non-Coding RNAs in Endometrial Physiopathology
Alessandro La Ferlita,Rosalia Battaglia,Francesca Andronico,Salvatore Caruso,Antonio Cianci,Michele Purrello,Cinzia Di Pietro +6 more
TL;DR: The function of non-coding RNAs in endometrial physiology is discussed, analysing their involvement in embryo implantation and their role inendometrial pathologies such as endometricrial cancer, endometriosis and chronic endometritis is explored.
Journal ArticleDOI
Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure
Patricia Sebastian-Leon,Nicolás Garrido,José Remohí,Antonio Pellicer,Antonio Pellicer,Patricia Diaz-Gimeno +5 more
TL;DR: The predictive results demonstrate that both displaced and disrupted WOIs exist and can present independently or together in the same RIF patient, and propose a new genomic approach that distinguishes between both types of RIF in thesame sample cohort.
References
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Journal ArticleDOI
Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women
Said Talbi,A.E. Hamilton,Kim Chi Vo,Suzana Tulac,Michael Toft Overgaard,Chrysoula Dosiou,N Le Shay,C.N. Nezhat,R Kempson,Bruce A. Lessey,Nihar R. Nayak,Linda C. Giudice +11 more
TL;DR: Endometrial samples obtained by two different sampling techniques from subjects who are as normal as possible in a human study and including those with unknown histology, can be classified by their molecular signatures and correspond to known phases of the menstrual cycle with identical results using two independent analytical methods.
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A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature
Patricia Diaz-Gimeno,José A. Horcajadas,José Antonio Martínez-Conejero,Francisco J. Esteban,Pilar Alamá,Antonio Pellicer,Carlos Simón +6 more
TL;DR: A genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies ofendometrial origin can be used clinically in reproductive medicine and gynecology and the transcriptomic signature is a potential endometrian receptivity biomarkers cluster.
Journal ArticleDOI
Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization.
TL;DR: It is suggested that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.
Journal ArticleDOI
Investigation and treatment of repeated implantation failure following IVF-ET
TL;DR: The suggested methods for evaluation and treatment of RIF are discussed: repeated hysteroscopy, myomectomy, endometrial stimulation, immunotherapy, preimplantation genetic screening (PGS), assisted hatching, zygote intra-Fallopian transfer (ZIFT), co-culture, blastocyst transfer, cytoplasmic transfer, tailoring stimulation protocols and salpingectomy for hydrosalpinges.
Journal ArticleDOI
Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology
Anne Riesewijk,Julio Martín,Roselinde van Os,José A. Horcajadas,Jan Polman,Antonio Pellicer,Sietse Mosselman,Carlos Simón +7 more
TL;DR: Gene expression profiles of pre-receptive versus receptive endometria obtained from the same fertile woman in the same menstrual cycle are compared to gain a global molecular understanding of human endometrial receptivity.