Journal ArticleDOI
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Maria Ruiz-Alonso,David Blesa,Patricia Diaz-Gimeno,Eva Gómez,Manuel Fernández-Sánchez,F. Carranza,Joan Carrera,F. Vilella,Antonio Pellicer,Carlos Simón +9 more
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TLDR
There is an increased percentage of WOI displacement in RIF patients compared with comparison group patients, leading to the concept of pET as a therapeutic strategy.About:
This article is published in Fertility and Sterility.The article was published on 2013-09-01. It has received 351 citations till now.read more
Citations
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Journal ArticleDOI
Will noninvasive methods surpass invasive for assessing gametes and embryos
Tim Sanchez,Emily A. Seidler,Emily A. Seidler,David K. Gardner,Daniel J. Needleman,Denny Sakkas +5 more
TL;DR: It is argued that analysis of metabolic function, using either spent medium or by novel microscopies, could provide the basis for selecting the embryo with the highest viability, and noninvasive embryo viability assessment will assist in embryo selection for transfer.
Journal ArticleDOI
The Endometrial Polarity Paradox: Differential Regulation of Polarity Within Secretory-Phase Human Endometrium.
Sarah T. Whitby,Sarah T. Whitby,Lois A. Salamonsen,Lois A. Salamonsen,Jemma Evans,Jemma Evans +5 more
TL;DR: Examination of defined polarity markers within human endometrium throughout the menstrual cycle identified downregulation of atypical protein kinase C, Stardust, Crumbs, and Scribble within the luminal-epithelial layer, with upregulation of Scribbles within the stromal compartment as the menstruation cycle progressed from the estrogen-dominated proliferative to progesterone-dominated secretory phase.
Journal ArticleDOI
Pinopode score around the time of implantation is predictive of successful implantation following frozen embryo transfer in hormone replacement cycles
Xiaoying Jin,Lijuan Zhao,D H Luo,Liu Liu,Yongdong Dai,X X Hu,Y Y Wang,Xiaona Lin,F Hong,Tin-Chiu Li,Songying Zhang +10 more
TL;DR: It is suggested that pinopode measurement may be of value in predicting pregnancy in women with infertility and undergoing frozen embryo transfer in hormone replacement cycles.
Journal ArticleDOI
Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway
TL;DR: In this article, the authors showed that baicalin significantly increased FUT4 mRNA and protein expression levels both in human endometrial cells and mouse endometrium tissue, and consistently elevated embryo adhesion rate during implantation in vitro and embryonic implantation competence in pregnant mouse.
Journal ArticleDOI
Downregulation of genes related to immune and inflammatory response in IVF implantation failure cases under controlled ovarian stimulation.
TL;DR: This work aims to study the genomics of endometrial receptivity in IF patients under controlled ovarian stimulation (COS) during which ET is generally practised in IVF.
References
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Journal ArticleDOI
Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women
Said Talbi,A.E. Hamilton,Kim Chi Vo,Suzana Tulac,Michael Toft Overgaard,Chrysoula Dosiou,N Le Shay,C.N. Nezhat,R Kempson,Bruce A. Lessey,Nihar R. Nayak,Linda C. Giudice +11 more
TL;DR: Endometrial samples obtained by two different sampling techniques from subjects who are as normal as possible in a human study and including those with unknown histology, can be classified by their molecular signatures and correspond to known phases of the menstrual cycle with identical results using two independent analytical methods.
Journal ArticleDOI
A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature
Patricia Diaz-Gimeno,José A. Horcajadas,José Antonio Martínez-Conejero,Francisco J. Esteban,Pilar Alamá,Antonio Pellicer,Carlos Simón +6 more
TL;DR: A genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies ofendometrial origin can be used clinically in reproductive medicine and gynecology and the transcriptomic signature is a potential endometrian receptivity biomarkers cluster.
Journal ArticleDOI
Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization.
TL;DR: It is suggested that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.
Journal ArticleDOI
Investigation and treatment of repeated implantation failure following IVF-ET
TL;DR: The suggested methods for evaluation and treatment of RIF are discussed: repeated hysteroscopy, myomectomy, endometrial stimulation, immunotherapy, preimplantation genetic screening (PGS), assisted hatching, zygote intra-Fallopian transfer (ZIFT), co-culture, blastocyst transfer, cytoplasmic transfer, tailoring stimulation protocols and salpingectomy for hydrosalpinges.
Journal ArticleDOI
Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology
Anne Riesewijk,Julio Martín,Roselinde van Os,José A. Horcajadas,Jan Polman,Antonio Pellicer,Sietse Mosselman,Carlos Simón +7 more
TL;DR: Gene expression profiles of pre-receptive versus receptive endometria obtained from the same fertile woman in the same menstrual cycle are compared to gain a global molecular understanding of human endometrial receptivity.