Journal ArticleDOI
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Maria Ruiz-Alonso,David Blesa,Patricia Diaz-Gimeno,Eva Gómez,Manuel Fernández-Sánchez,F. Carranza,Joan Carrera,F. Vilella,Antonio Pellicer,Carlos Simón +9 more
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TLDR
There is an increased percentage of WOI displacement in RIF patients compared with comparison group patients, leading to the concept of pET as a therapeutic strategy.About:
This article is published in Fertility and Sterility.The article was published on 2013-09-01. It has received 351 citations till now.read more
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Journal ArticleDOI
Fertile ground: human endometrial programming and lessons in health and disease
Jemma Evans,Lois A. Salamonsen,Lois A. Salamonsen,Amy Winship,Amy Winship,Ellen Menkhorst,Ellen Menkhorst,Guiying Nie,Guiying Nie,Caroline E. Gargett,Eva Dimitriadis,Eva Dimitriadis +11 more
TL;DR: The development of biomarkers for prediction of uterine diseases and pregnancy disorders and future avenues of investigation to improve fertility and enhance endometrial function are discussed.
Journal ArticleDOI
Frozen embryo transfer: a review on the optimal endometrial preparation and timing.
Shari Mackens,Samuel Santos-Ribeiro,A. van de Vijver,Annalisa Racca,L. Van Landuyt,Herman Tournaye,Christophe Blockeel,Christophe Blockeel +7 more
TL;DR: A standardized timing strategy based on the current available evidence which could assist in the harmonization and comparability of clinic practice and future trials is proposed, with special attention to the timing of the embryo transfer.
Journal ArticleDOI
What exactly is endometrial receptivity
Bruce A. Lessey,Steven L. Young +1 more
TL;DR: This review highlights the advances in the study of implantation from the perspective of the endometrium, normally a barrier to implantation, and predicts new advances will allow the early identification of defects in endometrial receptivity and provide new avenues for treatment that promote successful establishment of pregnancy.
Journal ArticleDOI
Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers
Signe Altmäe,Signe Altmäe,Mariann Koel,Mariann Koel,Urmo Võsa,Priit Adler,Marina Suhorutšenko,Triin Laisk-Podar,Viktorija Kukushkina,Merli Saare,Agne Velthut-Meikas,Kaarel Krjutškov,Lusine Aghajanova,P.G.L. Lalitkumar,Kristina Gemzell-Danielsson,Linda C. Giudice,Carlos Simón,Andres Salumets,Andres Salumets +18 more
TL;DR: A meta-analysis of endometrial-receptivity associated genes is performed using a robust rank aggregation (RRA) method, followed by enrichment analysis, and regulatory microRNA prediction, which identifies 57 meta-signature genes and involved pathways that could serve as promising and sought-after biomarkers ofendometrial receptivity, fertility and infertility.
Journal ArticleDOI
Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes?
TL;DR: The value of sperm selection is examined to see how much guidance for ART can be gleaned from the natural selection processes in vivo as well as recent developments in in vitro selection and preparation methods.
References
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Journal ArticleDOI
Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women
Said Talbi,A.E. Hamilton,Kim Chi Vo,Suzana Tulac,Michael Toft Overgaard,Chrysoula Dosiou,N Le Shay,C.N. Nezhat,R Kempson,Bruce A. Lessey,Nihar R. Nayak,Linda C. Giudice +11 more
TL;DR: Endometrial samples obtained by two different sampling techniques from subjects who are as normal as possible in a human study and including those with unknown histology, can be classified by their molecular signatures and correspond to known phases of the menstrual cycle with identical results using two independent analytical methods.
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A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature
Patricia Diaz-Gimeno,José A. Horcajadas,José Antonio Martínez-Conejero,Francisco J. Esteban,Pilar Alamá,Antonio Pellicer,Carlos Simón +6 more
TL;DR: A genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies ofendometrial origin can be used clinically in reproductive medicine and gynecology and the transcriptomic signature is a potential endometrian receptivity biomarkers cluster.
Journal ArticleDOI
Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization.
TL;DR: It is suggested that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.
Journal ArticleDOI
Investigation and treatment of repeated implantation failure following IVF-ET
TL;DR: The suggested methods for evaluation and treatment of RIF are discussed: repeated hysteroscopy, myomectomy, endometrial stimulation, immunotherapy, preimplantation genetic screening (PGS), assisted hatching, zygote intra-Fallopian transfer (ZIFT), co-culture, blastocyst transfer, cytoplasmic transfer, tailoring stimulation protocols and salpingectomy for hydrosalpinges.
Journal ArticleDOI
Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology
Anne Riesewijk,Julio Martín,Roselinde van Os,José A. Horcajadas,Jan Polman,Antonio Pellicer,Sietse Mosselman,Carlos Simón +7 more
TL;DR: Gene expression profiles of pre-receptive versus receptive endometria obtained from the same fertile woman in the same menstrual cycle are compared to gain a global molecular understanding of human endometrial receptivity.