The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Molecular Diagnostic Testing.
Kimberly E. Hanson,Angela M. Caliendo,Cesar A. Arias,Mary K. Hayden,Janet A. Englund,Mark J Lee,Mark Loeb,Robin Patel,Abdallah El Alayli,Osama Altayar,Payal M. Patel,Yngve Falck-Ytter,Valery Lavergne,Rebecca L. Morgan,M. Hassan Murad,Shahnaz Sultan,Adarsh Bhimraj,Reem A. Mustafa +17 more
TLDR
The IDSA panel weighed available diagnostic evidence and recommends nucleic acid testing for all symptomatic individuals suspected of having COVID-19, and testing is recommended for asymptomatic individuals with known or suspected contact with a CO VID-19 case.Abstract:
Background Accurate molecular diagnostic tests are necessary for confirming a diagnosis of coronavirus disease 2019 (COVID-19). Direct detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acids in respiratory tract specimens informs patient, healthcare institution and public health level decision-making. The numbers of available SARS-CoV-2 nucleic acid detection tests are rapidly increasing, as is the COVID-19 diagnostic literature. Thus, the Infectious Diseases Society of America (IDSA) recognized a significant need for frequently updated systematic reviews of the literature to inform evidence-based best practice guidance. Objective The IDSA's goal was to develop an evidence-based diagnostic guideline to assist clinicians, clinical laboratorians, patients and policymakers in decisions related to the optimal use of SARS-CoV-2 nucleic acid amplification tests. In addition, we provide a conceptual framework for understanding molecular diagnostic test performance, discuss the nuance of test result interpretation in a variety of practice settings and highlight important unmet research needs in the COVID-19 diagnostic testing space. Methods IDSA convened a multidisciplinary panel of infectious diseases clinicians, clinical microbiologists, and experts in systematic literature review to identify and prioritize clinical questions and outcomes related to the use of SARS-CoV-2 molecular diagnostics. Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to assess the certainty of evidence and make testing recommendations. Results The panel agreed on 17 diagnostic recommendations. Conclusions Universal access to accurate SARS-CoV-2 nucleic acid testing is critical for patient care, hospital infection prevention and the public response to the COVID-19 pandemic. Information on the clinical performance of available tests is rapidly emerging, but the quality of evidence of the current literature is considered moderate to very low. Recognizing these limitations, the IDSA panel weighed available diagnostic evidence and recommends nucleic acid testing for all symptomatic individuals suspected of having COVID-19. In addition, testing is recommended for asymptomatic individuals with known or suspected contact with a COVID-19 case. Testing asymptomatic individuals without known exposure is suggested when the results will impact isolation/quarantine/personal protective equipment (PPE) usage decisions, dictate eligibility for surgery, or inform solid organ or hematopoietic stem cell transplantation timing. Ultimately, prioritization of testing will depend on institutional-specific resources and the needs of different patient populations.read more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Severe covid-19 pneumonia: pathogenesis and clinical management.
TL;DR: In this article, high flow nasal cannula (HFNC) was used to avoid intubation in acute respiratory distress syndrome (CARDS) patients with severe SARS CoV-2 infection.
Journal ArticleDOI
Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection.
Seyed Hamid Safiabadi Tali,Jason J. LeBlanc,Zubi Sadiq,Oyejide Damilola Oyewunmi,Carolina Camargo,Bahareh Nikpour,Narges Armanfard,Selena M. Sagan,Sana Jahanshahi-Anbuhi +8 more
TL;DR: A review of the technologies used to detect SARS-CoV-2 in clinical laboratories as well as advances made for molecular, antigen-based, and immunological point-of-care testing, including recent developments in sensor and biosensor devices is presented in this paper.
Journal ArticleDOI
Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19:Serologic Testing.
Kimberly E. Hanson,Angela M. Caliendo,Cesar A. Arias,Janet A. Englund,Mary K. Hayden,Mark J Lee,Mark Loeb,Robin Patel,Osama Altayar,Abdallah El Alayli,Shahnaz Sultan,Yngve Falck-Ytter,Valery Lavergne,Rebecca L. Morgan,M. Hassan Murad,Adarsh Bhimraj,Reem A. Mustafa +16 more
TL;DR: This guideline highlights important unmet research needs pertaining to the use of anti-SARS-CoV-2 antibody tests for diagnosis, public health surveillance, vaccine development and the selection of convalescent plasma donors.
Journal ArticleDOI
Clinical update on COVID-19 for the emergency clinician: Presentation and evaluation
Brit Long,Brandon M Carius,Summer A Chavez,Stephen Y. Liang,William J. Brady,Alex Koyfman,Michael S. Gottlieb +6 more
TL;DR: The first in a two-part series on COVID-19 updates as mentioned in this paper provides a focused overview of the presentation and evaluation of the coronavirus disease of 2019 for emergency clinicians.
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TL;DR: Detailed virological analysis of nine cases of coronavirus disease 2019 (COVID-19) provides proof of active replication of the SARS-CoV-2 virus in tissues of the upper respiratory tract.
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