Journal ArticleDOI
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
TLDR
The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or repression and can be viewed as a functional module which acts to convert environmental signals into specific gene-regulatory programs.Abstract:
The Myc/Max/Mad network comprises a group of transcription factors whose distinct interactions result in gene-specific transcriptional activation or repression. A great deal of research indicates that the functions of the network play roles in cell proliferation, differentiation, and death. In this review we focus on the Myc and Mad protein families and attempt to relate their biological functions to their transcriptional activities and gene targets. Both Myc and Mad, as well as the more recently described Mnt and Mga proteins, form heterodimers with Max, permitting binding to specific DNA sequences. These DNA-bound heterodimers recruit coactivator or corepressor complexes that generate alterations in chromatin structure, which in turn modulate transcription. Initial identification of target genes suggests that the network regulates genes involved in the cell cycle, growth, life span, and morphology. Because Myc and Mad proteins are expressed in response to diverse signaling pathways, the network can be viewed as a functional module which acts to convert environmental signals into specific gene-regulatory programs.read more
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Histone deacetylases (HDACs): characterization of the classical HDAC family
Annemieke J.M. de Ruijter,Albert H. van Gennip,Huib N. Caron,Stephan Kemp,André B.P. van Kuilenburg +4 more
TL;DR: In this paper, a comprehensive overview of the structure, function and tissue distribution of members of the classical histone deacetylase (HDAC) family, in order to gain insight into the regulation of gene expression through HDAC activity is presented.
Journal ArticleDOI
Direct observation of individual endogenous protein complexes in situ by proximity ligation
Ola Söderberg,Mats Gullberg,Malin Jarvius,Karin Ridderstråle,Karl-Johan Leuchowius,Jonas Jarvius,Kenneth Wester,Per Hydbring,Fuad Bahram,Lars-Gunnar Larsson,Ulf Landegren +10 more
TL;DR: This method is used to show specific regulation of protein-protein interactions between endogenous Myc and Max oncogenic transcription factors in response to interferon-γ (IFN-γ) signaling and low-molecular-weight inhibitors.
Journal ArticleDOI
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.
Marc van de Wetering,Elena Sancho,Cornelis Verweij,Wim de Lau,Irma Oving,Adam Hurlstone,Karin van der Horn,Eduard Batlle,Damien Coudreuse,Anna-Pavlina G. Haramis,Menno Tjon-Pon-Fong,Petra Moerer,Maaike van den Born,Gwen Soete,Steven T. Pals,Martin Eilers,René H. Medema,Hans Clevers +17 more
TL;DR: The β-catenin/TCF-4 complex constitutes the master switch that controls proliferation versus differentiation in healthy and malignant intestinal epithelial cells.
Journal ArticleDOI
Reflecting on 25 years with MYC
Natalie Meyer,Linda Z. Penn +1 more
TL;DR: Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified and each incremental insight into MYC regulation and function has had an impact on numerous biological disciplines, including the understanding of molecular oncogenesis in general.
Journal ArticleDOI
ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis
Viswanathan Chinnusamy,Masaru Ohta,Siddhartha Kanrar,Byeong-ha Lee,Xuhui Hong,Manu Agarwal,Jian-Kang Zhu +6 more
TL;DR: The identification of ICE1 (inducer of CBF expression 1), an upstream transcription factor that regulates the transcription of CBFs genes in the cold, and its overexpression in wild-type plants enhances the expression of the CBF regulon in thecold and improves freezing tolerance of the transgenic plants.
References
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