Journal ArticleDOI
The PILATUS 1M detector.
Ch. Broennimann,E. F. Eikenberry,B. Henrich,Roland Horisberger,G. Huelsen,Ehmke Pohl,Bernd Schmitt,Clemens Schulze-Briese,M. Suzuki,Takashi Tomizaki,Hidenori Toyokawa,Armin Wagner +11 more
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TLDR
Determination of a refined electron density map of a macromolecular biological crystal using a silicon pixel detector for protein crystallography is made for the first time.Abstract:
The PILATUS 1M detector is a hybrid pixel array detector with over one million pixels that operate in single photon counting mode. The detector, designed for macromolecular crystallography, is the largest pixel array detector currently in use at a synchrotron. It is a modular system consisting of 18 multichip modules covering an area of 21 cm × 24 cm. The design of the components as well as the manufacturing of the detector including the bump-bonding was performed at the Paul Scherrer Institute (PSI). The use of a single photon counting detector for protein crystallography requires detailed studies of the charge collection properties of the silicon sensor. The 18 modules are read out in parallel, leading to a full frame readout-time of 6.7 ms. This allows crystallographic data to be acquired in fine-φ-slicing mode with continuous rotation of the sample. The detector was tested in several experiments at the protein crystallography beamline X06SA at the Swiss Light Source at PSI. Data were collected both in conventional oscillation mode using the shutter, as well as in a fine-φ-slicing mode. After applying all the necessary corrections to data from a thaumatin crystal, the processing of the conventional data led to satisfactory merging R-factors of the order of 8.5%. This allows, for the first time, determination of a refined electron density map of a macromolecular biological crystal using a silicon pixel detector.read more
Citations
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Journal ArticleDOI
High-Resolution Scanning X-ray Diffraction Microscopy
Pierre Thibault,Martin Dierolf,Andreas Menzel,Oliver Bunk,Christian David,Franz Pfeiffer,Franz Pfeiffer +6 more
TL;DR: A ptychographic imaging method is demonstrated that bridges the gap between CDI and STXM by measuring complete diffraction patterns at each point of a STXM scan.
Journal ArticleDOI
A SAXS/WAXS/GISAXS Beamline with Multilayer Monochromator
Alexander Hexemer,Wim Bras,James Glossinger,Eric Schaible,Eliot Gann,Richard A. Kirian,Alastair A. MacDowell,Matthew Church,Bruce Rude,Howard A. Padmore +9 more
TL;DR: In this article, the authors discuss the construction of a new SAXS/WAXS beamline at the Advanced Light Source at Lawrence Berkeley Laboratory, which is equipped with a multilayer monochromator in order to obtain a high X-ray flux.
Journal ArticleDOI
Advances in solid state photon detectors
Dieter Renker,E. Lorenz +1 more
TL;DR: Semiconductor photodiodes were developed in the early 'Forties approximately at the time when the photomultiplier tube became a commercial product (RCA 1939) as mentioned in this paper.
Journal ArticleDOI
Performance of single-photon-counting PILATUS detector modules
P. Kraft,Anna Bergamaschi,Ch. Broennimann,Roberto Dinapoli,E. F. Eikenberry,B. Henrich,Ian Johnson,Aldo Mozzanica,Christian M. Schlepütz,Philip R. Willmott,Bernd Schmitt +10 more
TL;DR: Characterization of PILATUS single-photon-counting X-ray detector modules regarding charge sharing, energy resolution and rate capability is presented and the performance of the detector was tested with surface diffraction experiments at the synchrotron.
Journal ArticleDOI
SwissFEL: The Swiss X-ray Free Electron Laser
Christopher J. Milne,Thomas Schietinger,M. Aiba,Arturo Alarcon,J. Alex,Alexander Anghel,Vladimir Arsov,Carl Beard,Paul Beaud,Simona Bettoni,M. Bopp,H. Brands,Manuel Brönnimann,Ingo Brunnenkant,Marco Calvi,A. Citterio,Paolo Craievich,Marta Csatari Divall,Mark Dällenbach,Michael D’Amico,Andreas Dax,Yunpei Deng,Alexander Dietrich,Roberto Dinapoli,Edwin Divall,Sladana Dordevic,Simon Ebner,Christian Erny,Hansrudolf Fitze,Uwe Flechsig,Rolf Follath,F. Frei,Florian Gärtner,Romain Ganter,Terence Garvey,Zheqiao Geng,I. Gorgisyan,C. Gough,A. Hauff,Christoph P. Hauri,Nicole Hiller,Tadej Humar,Stephan Hunziker,Gerhard Ingold,Rasmus Ischebeck,Markus Janousch,Pavle Juranić,M. Jurcevic,Maik Kaiser,Babak Kalantari,Roger Kalt,B. Keil,Christoph Kittel,Gregor Knopp,W. Koprek,Henrik T. Lemke,Thomas Lippuner,Daniel Llorente Sancho,Florian Löhl,C. Lopez-Cuenca,Fabian Märki,F. Marcellini,G. Marinkovic,Isabelle Martiel,Ralf Menzel,Aldo Mozzanica,Karol Nass,Gian Luca Orlandi,Cigdem Ozkan Loch,Ezequiel Panepucci,Martin Paraliev,Bruce D. Patterson,Bill Pedrini,Marco Pedrozzi,Patrick Pollet,Claude Pradervand,Eduard Prat,Peter Radi,Jean-Yves Raguin,S. Redford,Jens Rehanek,Julien Réhault,Sven Reiche,Matthias Ringele,J. Rittmann,Leonid Rivkin,Albert Romann,Marie Ruat,C. Ruder,Leonardo Sala,Lionel Schebacher,T. Schilcher,Volker Schlott,Thomas J. Schmidt,Bernd Schmitt,Xintian Shi,M. Stadler,L. Stingelin,Werner Sturzenegger,Jakub Szlachetko,D. Thattil,D. Treyer,A. Trisorio,Wolfgang Tron,S. Vetter,Carlo Vicario,Didier Voulot,Meitian Wang,Thierry Zamofing,Christof Zellweger,R. Zennaro,Elke Zimoch,Rafael Abela,Luc Patthey,Hans-Heinrich Braun +114 more
TL;DR: The SwissFEL X-ray Free Electron Laser (XFEL) facility as discussed by the authors started construction at the Paul Scherrer Institute (Villigen, Switzerland) in 2013 and will be ready to accept its first users in 2018 on the Aramis hard Xray branch.
References
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Book ChapterDOI
SHELXL: high-resolution refinement.
TL;DR: The program is designed to be easy to use and general for all space groups and uses a conventional structure-factor calculation rather than a fast Fourier transform (FFT) summation, which is much slower than programs written specifically for macromolecules.
Journal ArticleDOI
A pixel read-out chip for the PILATUS project
Ch. Brönnimann,R. Baur,E.F. Eikenberry,S. Kohout,M. Lindner,Bernd Schmitt,Roland Horisberger +6 more
TL;DR: The PILATUS project as mentioned in this paper is a hybrid pixel system with a size of 40×40 cm 2 having 2000×2000 pixels, which will be operated in single photon counting mode for 12-keV X-rays.
Journal ArticleDOI
Continuous sample rotation data collection for protein crystallography with the PILATUS detector
Ch. Brönnimann,E. F. Eikenberry,Roland Horisberger,G. Hülsen,Bernd Schmitt,Clemens Schulze-Briese,Takashi Tomizaki +6 more
TL;DR: The PILATUS detector as discussed by the authors is a large all silicon quantum-limited area X-ray detector for protein crystallography, with a three-module array with 1120 � 157 pixels covering an active area of 24.3 � 3.6 cm 2.
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