Journal ArticleDOI
The role of myelin and oligodendrocytes in axonal energy metabolism.
TLDR
Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails, including neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-12-01. It has received 260 citations till now. The article focuses on the topics: Myelin.read more
Citations
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Journal ArticleDOI
New Approaches to Analyse Axon-Oligodendrocyte Communication in vivo
Tim Czopka,Franziska Auer +1 more
TL;DR: An overview about this research area is provided, how zebrafish have helped understanding mechanisms of myelination are described, and how they may help addressing open questions related to the control of axon-oligodendrocyte interactions are discussed.
Charakterisierung panglialer Kommunikationsmechanismen im Bulbus olfactorius der Maus (Mus musculus L.)
TL;DR: In this paper, the interzellulare Kommunikation der Axone der olfaktorischen Rezeptorneurone and OECs was investigated.
Journal ArticleDOI
Feasibility of MRI Quantification of Myelin Water Fraction in the Fetal Guinea Pig Brain
S. Prakesh Sethi,Lanette J. Friesen-Waldner,Trevor Wade,Marc Courchesne,Karen Nygard,Ousseynou Sarr,Brian Sutherland,Timothy R. H. Regnault,Charles A. McKenzie +8 more
TL;DR: This study demonstrated the feasibility of MWI in assessing fetal brain myelin content in fetal guinea pigs using a multicomponent driven equilibrium single pulse observation of T1 and T2 approach.
Journal ArticleDOI
Pro-myelinating clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health.
TL;DR: In this paper , the authors showed that enhancing oligodendrocyte activity with a pharmaceutical drug, Clemastine, will prevent the chronic decline of microelectrode recording performance.
References
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
TL;DR: It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Journal ArticleDOI
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Bruce D. Trapp,Klaus-Armin Nave +1 more
TL;DR: Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Journal ArticleDOI
Axonal damage in acute multiple sclerosis lesions.
TL;DR: The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.
Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
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