Journal ArticleDOI
The role of myelin and oligodendrocytes in axonal energy metabolism.
TLDR
Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails, including neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-12-01. It has received 260 citations till now. The article focuses on the topics: Myelin.read more
Citations
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Dissertation
The role of astrocytes in murine models of toxic demyelination
TL;DR: It is confirmed that reactive astrocytes have protective effects in models of toxic demyelination in vivo, and enhanced hGFAP expression seems to modulate astroCytic chemokine expression, presumably via a reduced activation of the NF-κB pathway.
Posted ContentDOI
Oligodendrocyte dynamics dictate individual performance outcomes of working memory training in mice
Takahiro Shimizu,Stuart G. Nayar,Matthew Swire,Yi Jiang,Matt Grist,David M. Bannerman,Heidi Johansen-Berg,Katsutoshi Ogasawara,Koujiro Tohyama,William D. Richardson +9 more
TL;DR: This paper showed that myelin sheath formation was also required for non-motor learning and cognition, using T-maze and radial arm maze tasks that tax spatial working memory.
Change In Processing Speed And Its Associations With Cerebral White Matter Microstructure
TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” to characterize the response of the immune system to the presence of foreign substance such as DNA.
Journal ArticleDOI
The common marmoset ( Callithrix jacchus ): a relevant preclinical model of human (auto)immune-mediated inflammatory disease of the brain
TL;DR: The preclinical relevance of the experimental autoimmune encephalomyelitis model in common marmosets (Callithrix jacchus), a small-bodied neotropical primate, is reviewed.
References
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
TL;DR: It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Journal ArticleDOI
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Bruce D. Trapp,Klaus-Armin Nave +1 more
TL;DR: Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Journal ArticleDOI
Axonal damage in acute multiple sclerosis lesions.
TL;DR: The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.
Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
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