Journal ArticleDOI
The role of myelin and oligodendrocytes in axonal energy metabolism.
TLDR
Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails, including neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-12-01. It has received 260 citations till now. The article focuses on the topics: Myelin.read more
Citations
More filters
Book ChapterDOI
Chapter 3 – Oligodendrocyte differentiation
E.S. Mathews,B. Appel +1 more
TL;DR: Zebrafish offer several advantages to investigating myelination, including the use of transgenic reporter lines, live imaging, forward genetic screens, chemical screens, and reverse genetic approaches, and these tools and approaches have provided new insights into the regulatory mechanisms that guide myelinations.
Journal ArticleDOI
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2
Nathalie Escande-Beillard,Nathalie Escande-Beillard,Nathalie Escande-Beillard,Abigail Loh,Sahar N. Saleem,Kohei Kanata,Yui Hashimoto,Umut Altunoglu,Artina Metoska,Joanes Grandjean,Fui Mee Ng,Oz Pomp,Nithya Baburajendran,Joyner Wong,Jeffrey Hill,E. Beillard,Patrick Cozzone,Maha S. Zaki,Hülya Kayserili,Hiroshi Hamada,Hidetaka Shiratori,Hidetaka Shiratori,Bruno Reversade +22 more
TL;DR: The crystal structure of the PYCR2 apo-enzyme is reported and it is found that knocking out Pycr2 in mice phenocopies the human disorder and depletes PY CR1 levels in neural lineages and could be partially reversed by SHMT2 knockdown.
Journal ArticleDOI
Gene network underlying the glial regenerative response to central nervous system injury
TL;DR: Drosophila findings provide insights into gene functions that could be manipulated in stem cells and progenitors for therapeutic repair and feedback loops between these genes enable a surge in proliferation in response to injury and ensuing differentiation.
Journal ArticleDOI
Local energy on demand: Are 'spontaneous' astrocytic Ca2+-microdomains the regulatory unit for astrocyte-neuron metabolic cooperation?
TL;DR: The understanding of these local regulatory and metabolic interactions will be fundamental to fully appreciate the complexity of brain energy homeostasis as well as its failure in disease and may shed new light on the controversy about neuron-glia bi-directional signaling at the tripartite synapse.
Journal ArticleDOI
Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning.
Ladina Hösli,Noemi Binini,Kim David Ferrari,Laetitia Thieren,Zoe J Looser,Marc Zuend,Henri S. Zanker,Stewart Berry,Martin Holub,Wiebke Möbius,Torben Ruhwedel,Klaus-Armin Nave,Christian Giaume,Bruno Weber,Aiman S. Saab +14 more
TL;DR: In this article , the authors show that hippocampal CA1 neuron excitability, excitatory synaptic transmission, and long-term potentiation are significantly affected, and behavioral inspection reveals deficits in sensorimotor performance and complete lack of spatial learning and memory.
References
More filters
Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
TL;DR: It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Journal ArticleDOI
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Bruce D. Trapp,Klaus-Armin Nave +1 more
TL;DR: Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Journal ArticleDOI
Axonal damage in acute multiple sclerosis lesions.
TL;DR: The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.
Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
Related Papers (5)
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Ursula Fünfschilling,Lotti Marianna Supplie,Don J. Mahad,Don J. Mahad,Susann Boretius,Aiman S. Saab,Julia M. Edgar,Bastian G. Brinkmann,Celia M. Kassmann,Iva D. Tzvetanova,Wiebke Möbius,Francisca Diaz,Dies Meijer,Ueli Suter,Bernd Hamprecht,Michael W. Sereda,Carlos T. Moraes,Jens Frahm,Sandra Goebbels,Klaus-Armin Nave +19 more
Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
Ian R. Griffiths,Matthias Klugmann,Matthias Klugmann,Matthias Klugmann,Thomas J. Anderson,Thomas J. Anderson,Thomas J. Anderson,Donald Yool,Donald Yool,Donald Yool,Christine E. Thomson,Christine E. Thomson,Christine E. Thomson,Markus H. Schwab,Markus H. Schwab,Markus H. Schwab,Armin Schneider,Armin Schneider,Armin Schneider,Frank Zimmermann,Frank Zimmermann,Frank Zimmermann,Mailise McCulloch,Mailise McCulloch,Mailise McCulloch,Nancy Nadon,Nancy Nadon,Nancy Nadon,Klaus-Armin Nave,Klaus-Armin Nave,Klaus-Armin Nave +30 more