Journal ArticleDOI
The role of myelin and oligodendrocytes in axonal energy metabolism.
TLDR
Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails, including neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-12-01. It has received 260 citations till now. The article focuses on the topics: Myelin.read more
Citations
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Journal ArticleDOI
Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination.
TL;DR: In this paper, the authors review recent findings addressing this reciprocal relationship in which neurons alter oligodendroglial form and oligodenrocytes conversely modulate neuronal function.
Journal ArticleDOI
Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia
Andrea Trevisiol,Kathrin Kusch,Anna M. Steyer,Ingo Gregor,Christos Nardis,Ulrike Winkler,Susanne Köhler,Alejandro Restrepo,Wiebke Möbius,Hauke B. Werner,Klaus-Armin Nave,Johannes Hirrlinger,Johannes Hirrlinger +12 more
TL;DR: Surprisingly, when Plpnull/y optic nerves are challenged with transient glucose deprivation, both ATP levels and CAP decline slower, but recover faster upon reperfusion of glucose, implying that complex metabolic alterations of the axon–myelin unit contribute to the phenotype of Plp null/y mice.
Journal ArticleDOI
Differentiating between axonal damage and demyelination in healthy aging by combining diffusion-tensor imaging and diffusion-weighted spectroscopy in the human corpus callosum at 7 T.
Francesca Branzoli,Francesca Branzoli,Ece Ercan,Romain Valabregue,Romain Valabregue,Emily T. Wood,Mathijs Buijs,Andrew G. Webb,Itamar Ronen +8 more
TL;DR: It was concluded that the possible intra-axonal changes associated with normal aging processes are below the detection level of diffusion-weighted magnetic resonance spectroscopy in the age range investigated.
Proteomic Profiling in the Brain of CLN1 Disease Model Reveals Affected Functional Modules
Saara Tikka,Evanthia Monogioudi,Athanasios Gotsopoulos,Rabah Soliymani,Francesco Pezzini,Enzo Scifo,Enzo Scifo,Kristiina Uusi-Rauva,Jaana Tyynelä,Marc Baumann,Anu Jalanko,Anu Jalanko,Alessandro Simonati,Maciej Lalowski +13 more
TL;DR: In this paper, a combination of laser capture microdissection-based quantitative liquid chromatography tandem mass spectrometry (MS) and matrix-assisted laser desorption/ionization time-of-flight MS imaging was used to quantify/visualize the changes in protein expression in disease-affected brain thalamus and cerebral cortex tissue slices, respectively.
Journal ArticleDOI
Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex
TL;DR: The unique pattern of Golli-MBP expression across the lifespan suggests that it supports high levels of neuroimmune interaction in cortical development and in aging.
References
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
TL;DR: It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Journal ArticleDOI
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Bruce D. Trapp,Klaus-Armin Nave +1 more
TL;DR: Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Journal ArticleDOI
Axonal damage in acute multiple sclerosis lesions.
TL;DR: The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.
Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
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