Journal ArticleDOI
The role of myelin and oligodendrocytes in axonal energy metabolism.
TLDR
Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails, including neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-12-01. It has received 260 citations till now. The article focuses on the topics: Myelin.read more
Citations
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Journal ArticleDOI
Nerve regeneration: Specific metabolic demands?
TL;DR: Glycolytic oligodendrocytes were shown to be fully viable and able to maintain axonal support, most likely by exporting the cellular excess of glycolysis products (lactate) via monocarboxylate transporters (MCTs) to axons in the CNS.
Journal ArticleDOI
Current Insights Into Oligodendrocyte Metabolism and Its Power to Sculpt the Myelin Landscape
Mohanlall Narine,Holly Colognato +1 more
TL;DR: It is highlighted how certain inputs can regulate oligodendroglial metabolism, including extrinsic and intrinsic mediators of cellular signaling, pharmacological compounds, and even dietary interventions.
DissertationDOI
Calcium-mediated mechanisms of retinal ganglion cell degeneration during autoimmune optic neuritis
TL;DR: It is hypothesised that an initial retinal pathology may lead to Ca2+-mediated cytoskeleton reorganization and axonal transport deficits in the optic nerve that could affect axonal integrity, as observed during iAON.
Journal ArticleDOI
Neuron‐glia (mis)interactions in brain energy metabolism during aging
TL;DR: In this paper , a review of the metabolic interactions between glial cells and neurons during aging is presented, emphasizing aging as the crucial risk factor for neurodegenerative/neuroinflammatory diseases.
Journal ArticleDOI
Neuronal energy use and brain evolution
TL;DR: In this paper , the authors consider how advantageous it might be to have eyes on our hands, rather than on our faces, to improve depth perception by the greater distance between the eyes, and it would be easy to look into relatively inaccessible spaces by appropriate movement of the hands.
References
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
TL;DR: It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Journal ArticleDOI
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Bruce D. Trapp,Klaus-Armin Nave +1 more
TL;DR: Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Journal ArticleDOI
Axonal damage in acute multiple sclerosis lesions.
TL;DR: The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.
Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
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