Journal ArticleDOI
The role of myelin and oligodendrocytes in axonal energy metabolism.
TLDR
Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails, including neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-12-01. It has received 260 citations till now. The article focuses on the topics: Myelin.read more
Citations
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Journal ArticleDOI
Lactate transporters as therapeutic targets in cancer and inflammatory diseases.
TL;DR: The therapeutic potential of targeting lactate transporters and drugs that are already in clinical use for cancer and the opportunity to develop new therapeutics for inflammation and cancer are discussed.
Book ChapterDOI
Oligodendrocyte precursor cells as a therapeutic target for demyelinating diseases.
TL;DR: OPC biology, myelination, and possible pharmacological targets for promoting the differentiation of OPCs as a strategy to enhance remyelination are discussed, including the potential for nanoscale delivery.
Journal ArticleDOI
Differential regulation of autophagy during metabolic stress in astrocytes and neurons.
Aditi Kulkarni,Audrey Dong,Vineet Vinay Kulkarni,Jessica A. Chen,Olivia Laxton,Anip Anand,Sandra Maday +6 more
TL;DR: The study reveals the complexity of regulating autophagy in different paradigms of metabolic stress, as well as in different cell types of the brain, and raises important implications for how neurons and glia may collaborate to maintain homeostasis in the brain.
Journal ArticleDOI
Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons
Katja A. Lüders,Stefan Nessler,Kathrin Kusch,Julia Patzig,Ramona B. Jung,Wiebke Möbius,Wiebke Möbius,Klaus-Armin Nave,Klaus-Armin Nave,Hauke B. Werner +9 more
TL;DR: It was found that 6 months after targeting the Plp‐gene the abundance of PLP in CNS myelin was about halved, probably reflecting that myelin is slowly turned over in the adult brain, and this reduction by 50% was sufficient to cause the entire spectrum of neuropathological changes previously associated with the developmental lack ofPLP.
Journal ArticleDOI
Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Aging Mice Visualized by Ex Vivo Live Multiphoton Imaging
Khalil S. Rawji,Janson Kappen,Weiwen Tang,Wulin Teo,Jason R. Plemel,Peter K. Stys,V. Wee Yong +6 more
TL;DR: It is reported that myeloid cells within demyelinated lesions of aging mice have reduced motility, surveillance, and phagocytic activity, suggesting an intralesional impairment that may contribute to the age-related decline in remyelination efficiency.
References
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
TL;DR: It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Journal ArticleDOI
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Bruce D. Trapp,Klaus-Armin Nave +1 more
TL;DR: Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Journal ArticleDOI
Axonal damage in acute multiple sclerosis lesions.
TL;DR: The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.
Journal ArticleDOI
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee,Brett M. Morrison,Yun Li,Sylvain Lengacher,Mohamed H. Farah,Paul N. Hoffman,Yiting Liu,Akivaga Tsingalia,Lin Jin,Ping Wu Zhang,Luc Pellerin,Pierre J. Magistretti,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
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