The Role of Vitamin D in Disease Progression in Early Parkinson's Disease.
Isobel Sleeman,Terry J. Aspray,Rachael A Lawson,Shirley Coleman,Gordon W Duncan,Tien K. Khoo,Inez Schoenmakers,Lynn Rochester,David J. Burn,Alison J. Yarnall +9 more
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TLDR
There was a small but significant association between vitamin D status at baseline and disease motor severity at 36 months and patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls.Abstract:
Background:
Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients.
Objective:
The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls and to assess if there was an association with clinical outcomes (disease severity, cognition and falls) over the 36-month follow up period.
Methods:
A prospective observational study of newly diagnosed PD patients in the North East of England with age-matched controls (PD, n = 145; control, n = 94). Serum 25(OH)D was assessed at baseline and 18 months. Participants underwent clinical assessment at baseline, 18 and 36 months. One hundred and ten participants with PD also took part in a prospective falls study.
Results:
Mean serum 25(OH)D concentrations were lower in PD than control participants at baseline (44.1±21.7 vs. 52.2±22.1 nmol/L, p < 0.05) and 18 months (44.2±23.6 vs. 55.7±28.8 nmol/L, p < 0.05). Baseline serum 25(OH)D concentration, age, motor score and dosage of dopaminergic medication were significant predictors of variance of motor severity at 36 months ((ΔR2 = 0.039, F = 6.6, p < 0.01). Serum 25(OH)D was not associated with cognition or falls during the follow up period.
Conclusions:
Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, which may have implications in terms of bone health and fracture risk. There was a small but significant association between vitamin D status at baseline and disease motor severity at 36 months.read more
Citations
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Journal ArticleDOI
Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state.
TL;DR: It is proposed that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings.
Journal ArticleDOI
Potential role of vitamin d in the elderly to resist covid-19 and to slow progression of parkinson’s disease
TL;DR: It is concluded that the daily supplementation of 2000–5000 IU/day of vitamin D3 in older adults with PD has the potential to slow the progression of PD while also potentially offering additional protection against COVID-19.
Journal ArticleDOI
Benefits of Vitamins in the Treatment of Parkinson's Disease.
TL;DR: Current clinical evidence indicates that proper supplementation of various vitamins can reduce the incidence of PD in the general population and improve the clinical symptoms of patients with PD; nevertheless, the safety of regular vitamin supplements still needs to be highlighted.
Journal ArticleDOI
Non-Skeletal Activities of Vitamin D: From Physiology to Brain Pathology
Giulia Bivona,Luisa Agnello,Chiara Bellia,Giorgia Iacolino,Concetta Scazzone,Bruna Lo Sasso,Marcello Ciaccio +6 more
TL;DR: The extra-skeletal actions of vitamin D are summarized, focusing its role in immunomodulation and brain function, and the issue of lacking standardized literature data concerning the usefulness ofitamin D as a biomarker in AD and PD is reported.
Journal ArticleDOI
Association Between Serum Vitamin D Levels and Parkinson's Disease: A Systematic Review and Meta-Analysis
TL;DR: Serum vitamin D levels are inversely associated with the risk and severity of Parkinson's disease (PD) and prompt the adjunctive therapeutic decisions about vitamin D replacement in PD.
References
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TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
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TL;DR: Controversy over the effectiveness of therapeutic measures for parkinsonism is due partially to this wide variability and to the paucity of clinical information about the natural history of the syndrome.
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Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results.
Christopher G. Goetz,Barbara C. Tilley,Stephanie R. Shaftman,Glenn T. Stebbins,Stanley Fahn,Pablo Martinez-Martin,Werner Poewe,Cristina Sampaio,Matthew B. Stern,Richard Dodel,Bruno Dubois,Robert G. Holloway,Joseph Jankovic,Jaime Kulisevsky,Anthony E. Lang,Andrew J. Lees,Sue Leurgans,Peter A. LeWitt,David L. Nyenhuis,C. Warren Olanow,Olivier Rascol,Anette Schrag,Jeanne A. Teresi,Jacobus J. van Hilten,Nancy R. LaPelle,Pinky Agarwal,Saima Athar,Yvette Bordelan,Helen Bronte-Stewart,Richard Camicioli,Kelvin L. Chou,Wendy Cole,Arif Dalvi,Holly Delgado,Alan Diamond,Jeremy P.R. Dick,John E. Duda,Rodger J. Elble,Carol Evans,V. G. H. Evidente,Hubert H. Fernandez,Susan H. Fox,Joseph H. Friedman,Robin D. Fross,David A. Gallagher,Deborah A. Hall,Neal Hermanowicz,Vanessa K. Hinson,Stacy Horn,Howard I. Hurtig,Un Jung Kang,Galit Kleiner-Fisman,Olga Klepitskaya,Katie Kompoliti,Eugene C. Lai,Maureen L. Leehey,Iracema Leroi,Kelly E. Lyons,Terry McClain,Steven W. Metzer,Janis M. Miyasaki,John C. Morgan,Martha Nance,Joanne Nemeth,Rajesh Pahwa,Sotirios A. Parashos,Jay S. Schneider,Kapil D. Sethi,Lisa M. Shulman,Andrew Siderowf,Monty Silverdale,Tanya Simuni,Mark Stacy,Robert Malcolm Stewart,Kelly L. Sullivan,David M. Swope,Pettaruse M. Wadia,Richard Walker,Ruth H. Walker,William J. Weiner,Jill Wiener,Jayne R. Wilkinson,Joanna M. Wojcieszek,Summer C. Wolfrath,Frederick Wooten,Allen Wu,Theresa A. Zesiewicz,Richard M. Zweig +87 more
TL;DR: The combined clinimetric results of this study support the validity of the MDS‐UPDRS for rating PD.