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The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure
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This article is published in JAMA Internal Medicine.The article was published on 1997-01-01 and is currently open access. It has received 5537 citations till now.read more
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Diuretic Therapy, the α-Adducin Gene Variant, and the Risk of Myocardial Infarction or Stroke in Persons With Treated Hypertension
Bruce M. Psaty,Nicholas L. Smith,Susan R. Heckbert,H. L. Vos,Rozenn N. Lemaitre,Alexander P. Reiner,David S. Siscovick,Joshua C. Bis,Thomas Lumley,W. T. Longstreth,Frits R. Rosendaal +10 more
TL;DR: In carriers of the adducin variant, diuretic therapy was associated with a lower risk of combined MI or stroke than other antihypertensive therapies, and this large subgroup of the hypertensive population may be especially likely to benefit from low-dose diUREtic therapy.
Journal ArticleDOI
Relations of Plasma Matrix Metalloproteinase-9 to Clinical Cardiovascular Risk Factors and Echocardiographic Left Ventricular Measures The Framingham Heart Study
Johan Sundström,Jane C. Evans,Emelia J. Benjamin,Daniel Levy,Martin G. Larson,Douglas B. Sawyer,Deborah A. Siwik,Wilson S. Colucci,Patrice Sutherland,Peter W.F. Wilson,Ramachandran S. Vasan +10 more
TL;DR: In a community-based sample, detectable plasma MMP-9 levels were associated with increased LV diastolic dimensions and increased wall thickness in men, indicating that plasma M MP-9 level may be a marker for cardiac extracellular matrix degradation, a process involved in LV remodeling.
Journal ArticleDOI
Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study.
Ming Hsiung Hsieh,Paul Chan,Yuh Mou Sue,Ju Chi Liu,Toong Hua Liang,Tsuei Yuen Huang,Brian Tomlinson,Moses S. S. Chow,Pai Feng Kao,Yi Jen Chen +9 more
TL;DR: In this 2-year study in Chinese patients with mild hypertension, oral stevioside significantly decreased SBP and DBP compared with placebo, and QOL was improved, and no significant adverse effects were noted.
Journal ArticleDOI
Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk.
Kristen M. Kennedy,Naftali Raz +1 more
TL;DR: The observed pattern of effects suggests that vascular risk may drive the expansion of age-related white matter damage from anterior to posterior regions.
Journal ArticleDOI
Prevalence and correlates of elevated serum creatinine levels: the Framingham Heart Study.
Bruce F. Culleton,Martin G. Larson,Jane C. Evans,Peter W.F. Wilson,Brendan J. Barrett,Patrick S. Parfrey,Daniel Levy +6 more
TL;DR: Elevated SCr levels are common in the community and are strongly associated with older age, treatment for hypertension, and diabetes, and longitudinal studies are warranted to determine the clinical outcomes of individuals with elevated levels of SCr.
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