The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein.
E. Li,Ira Tabas,Stuart Kornfeld +2 more
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The synthesis of the complex-type oligosaccharide unit of the vesicular stomatitis virus G protein is initiated by the en bloc transfer of a high molecular weight oligosACcharide from a lipid carrier to the nascent polypeptide.About:
This article is published in Journal of Biological Chemistry.The article was published on 1978-11-10 and is currently open access. It has received 398 citations till now. The article focuses on the topics: Oligosaccharide & Mannose.read more
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Biological Roles of Glycans
TL;DR: It is time for the diverse functional roles of glycans to be fully incorporated into the mainstream of biological sciences, as they are no different from other major macromolecular building blocks of life, simply more rapidly evolving and complex.
Journal ArticleDOI
Inhibitors of the Biosynthesis and Processing of N-Linked Oligosaccharide Chains
TL;DR: A number of inhibitors have been identified that interfere with glycoprotein biosynthesis, processing, or transport, such as tunicamycin, tridecaptin, and flavomycin this paper.
Inhibitors of the biosynthesis and processing of n-linked
TL;DR: A number of glycoproteins have oligosaccharides linked to protein in a GlcNAc----asparagine bond that are either of the complex, the high-mannose or the hybrid structure and a number of inhibitors have been identified that interfere with glycoprotein biosynthesis, processing, or transport.
Journal ArticleDOI
The carbohydrate-binding specificity of pea and lentil lectins. Fucose is an important determinant.
TL;DR: Glycopeptide binding to lentil lectin-Sepharose was enhanced by the exposure of terminal N-acetylglucosamine residues on the glycopeptides, whereas binding to pea lectin -Sepharoses was enhancedBy the exposure to terminal mannose residues, and the differences in carbohydrate binding specificity were exploited to fractionate a mixture of [2-3H]mannose-labeled glycoproteins derived from mouse lymphoma cell gly
Book ChapterDOI
Primary structure of glycoprotein glycans: basis for the molecular biology of glycoproteins.
TL;DR: This chapter elaborates the primary structure and metabolism of the N -linked glycans, and presents the hypothesis that the catabolism of N -acetyl-lactosainine glycans starts by the action of endo-2-acetamido- 2-deoxy-β- D -glucosidases in liberating oligosaccharides that are then degraded by exoglycosidases.
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Mannosyltransferase activity in calf pancreas microsomes. Formation of 14C-labeled lipid-linked oligosaccharides from GDP-D-[14C]mannose and pancreatic dolichyl beta-D-[14C]mannopyranosyl phosphate.
TL;DR: Evidence was obtained to show that the dolichyl beta-D-[14C]mannopyranosyl phosphate was serving as donor without prior conversion to GDP-D-mannose, and evidence was obtained that at least some of the oligosaccharides were linked to dlichol through a pyrophosphate group.