The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein.
E. Li,Ira Tabas,Stuart Kornfeld +2 more
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The synthesis of the complex-type oligosaccharide unit of the vesicular stomatitis virus G protein is initiated by the en bloc transfer of a high molecular weight oligosACcharide from a lipid carrier to the nascent polypeptide.About:
This article is published in Journal of Biological Chemistry.The article was published on 1978-11-10 and is currently open access. It has received 398 citations till now. The article focuses on the topics: Oligosaccharide & Mannose.read more
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Journal ArticleDOI
Transfer of mannose from GDP-mannose to lipid-linked oligosaccharide by soluble mannosyl transferase
James P. Spencer,Alan D. Elbein +1 more
TL;DR: Data demonstrate that at least some of the alpha-linked mannose residues in the heptasaccharide-lipid are donated directly from GDP-mannose, which had the same migration properties as the oligosaccharides that accumulates in the presence of amphomycin.
Book ChapterDOI
[35] N-asparagine-linked oligosaccharides: Biosynthesis of the lipid-linked oligosaccharides
TL;DR: This chapter primarily summarizes the in vivo studies, where pulse-labeling is used to identify intermediates and determine precursor-product relationships, and the relative ease in manipulating incubation conditions to modify and test the biosynthetic machinery.
Journal ArticleDOI
The biosynthetic pathway of the asparagine-linked oligosaccharides of glycoproteins
TL;DR: Studies of glycoproteins produced by virus-infected cells have shown that the glucose-containing oligosaccharide is transferred to protein, then the glucose and some mannose residues are removed and acetlyglucosamine, galactose and sialic acid are added.
Book ChapterDOI
Oligosaccharide processing during glycoprotein biosynthesis
TL;DR: A study of oligosaccharide processing in vesicular stomatitis virus-infected Chinese hamster ovary cells and how it is processed by the removal of glucose and mannose residues is presented.
Journal ArticleDOI
Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype.
Ghiabe-Henri Guibinga,Frederick L. Hall,Erlinda M. Gordon,Erkki Ruoslahti,Theodore Friedmann +4 more
TL;DR: In this paper, the authors demonstrate assembly and production of MLV-based and HIV-1-based vector particles using VSV-G proteins modified by the insertion of a peptide ligand into a site corresponding to amino acid position 24 of the native VSVG molecule.
References
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TL;DR: Modifications are introduced, based on a test given by Feigl for reducing sugars, which eliminate the heating step, and in which the reagents are applied in organic solvents, thus removing the danger of migration of the sugar spots.
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Determination of aminosugar linkages in glycolipids by methylation: Aminosugar linkages of ceramide pentasaccharides of rabbit erythrocytes and of Forssman antigen☆
TL;DR: This method was successfully applied to analysis of aminosugar linkages in blood group B-active ceramide pentasaccharide from rabbit erythrocytes and in Forssman antigen of equine spleen.
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The role of polyprenol-linked sugars in glycoprotein synthesis.
C J Waechter,W J Lennarz +1 more
TL;DR: The chiral stationary phase for lipid-Linked Monosaccharides showed good chiral recognition ability towards various lipids, and this property has been generalized to other lipids as well.
Book ChapterDOI
[90] α-Mannosidase, β-N-acetylhexosaminidase, and β-galactosidase from jack bean meal
Yu-Teh Li,Su-Chen Li +1 more
Journal ArticleDOI
Structural studies of two ovalbumin glycopeptides in relation to the endo-beta-N-acetylglucosaminidase specificity.
T Tai,Katsuko Yamashita,M Ogata-Arakawa,Norio Koide,Takashi Muramatsu,Shintaro Iwashita,Y Inoue,Akira Kobata +7 more
TL;DR: The presence of the unsubstituted alpha-mannosyl residue linked at the C-3 position of the terminal mannose of Manbeta1 leads to 4 GlcNAcAsn core must be essential for the action of the enzyme.