Therapeutic Potential of Triptolide as an Anti-Inflammatory Agent in Dextran Sulfate Sodium-Induced Murine Experimental Colitis.
Bufu Tang,Jinyu Zhu,Baohui Zhang,Fazong Wu,Fazong Wu,Yajie Wang,Yajie Wang,Qiaoyou Weng,Shiji Fang,Liyun Zheng,Yang Yang,Yang Yang,Rongfang Qiu,Rongfang Qiu,Minjiang Chen,Minjiang Chen,Min Xu,Min Xu,Zhongwei Zhao,Zhongwei Zhao,Jiansong Ji,Jiansong Ji +21 more
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TLDR
Investigation of the anti-inflammatory effects of triptolide in a dextran sulfate sodium (DSS)-induced mouse colitis model and LPS-activated macrophages revealed PDE4B as a target molecule, thus providing new ideas for the treatment of IBD.Abstract:
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic and incurable inflammatory diseases involving the gastrointestinal tract. In this study, we investigated the anti-inflammatory effects of triptolide in a dextran sulfate sodium (DSS)-induced mouse colitis model and LPS-activated macrophages and explored the specific molecular mechanism(s). In mice, triptolide treatment showed significant relief and protection against colitis, and it markedly reduced the inflammatory responses of human monocytes and mouse macrophages. Pharmacological analysis and weighted gene co-expression network analysis (WGCNA) suggested that PDE4B may be an important potential targeting molecule for IBD. Exploration of the specific mechanism of action indicated that triptolide reduced the production of ROS, inhibited macrophage infiltration and M1-type polarization by activating the NRF2/HO-1 signaling pathway, and inhibited the PDE4B/AKT/NF-κB signaling cascade, which may help weaken the intestinal inflammatory response. Our findings laid a theoretical foundation for triptolide as a treatment for IBD and revealed PDE4B as a target molecule, thus providing new ideas for the treatment of IBD.read more
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Atractylenolide-1 targets SPHK1 and B4GALT2 to regulate intestinal metabolism and flora composition to improve inflammation in mice with colitis.
TL;DR: In this paper , the efficacy and mechanism of atractylenolide-1 in treating ulcerative colitis (UC) were investigated in a dextran sulfate sodium (DSS)-induced UC mouse model.
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Recent advancement on development of drug-induced macrophage polarization in control of human diseases.
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