Journal ArticleDOI
Thermodynamic analysis of the permeability of biological membranes to non-electrolytes
Ora Kedem,Aharon Katchalsky +1 more
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TLDR
The equations derived here have been applied to various permeability measurements found in the literature, such as the penetration of heavy water into animal cells, permeability of blood vessels, threshold concentration of plasmolysis and relaxation experiments with artificial membranes.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1958-01-01. It has received 1960 citations till now. The article focuses on the topics: Membrane & Permeability (earth sciences).read more
Citations
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Lens intracellular hydrostatic pressure is generated by the circulation of sodium and modulated by gap junction coupling.
TL;DR: Data are consistent with hypotheses: fluid circulates through the lens; the intracellular leg of fluid circulation is through gap junction channels and is driven by hydrostatic pressure; and the fluid flow is generated by membrane transport of sodium.
Journal ArticleDOI
Multidimensional Pharmacokinetic Models Applied to the Design of Drug-Eluting Stents
TL;DR: The aim of this work is to show how mathematical models and numerical simulations can help to identify the desired physical properties of the stent coating in order to ensure a desired drug-release rate.
Journal ArticleDOI
Amphotericin B membrane action: role for two types of ion channels in eliciting cell survival and lethal effects.
TL;DR: A cell model is developed that serves as a framework for understanding how the intracellular K+ and Na+ concentration changes induced by the cation-selective AmB channels enhance multiple survival response pathways before they are overcome by the more sustained ion fluxes, Ca2+-dependent apoptotic events and cell lysis effects that are associated with the formation of AmB aqueous pores.
Journal ArticleDOI
Vascular permeability and transvascular fluid and protein transport in the dog lung.
TL;DR: Pulmonary capillary permeability characteristics indicate a heteroporous membrane system, andoretical considerations indicate that only the two largest protein fractions achieved filtration-independent concentrations in pulmonary lymph, even at the highest filTration rates.
References
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Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability.
TL;DR: Theoretical and experimental studies on the sieving of molecules by ultrafiltration through porous membranes indicate that an effective pore diameter of at least IOO A would be required to explain permeability of this magnitude.
Journal ArticleDOI
Passage of Molecules Through Capillary Walls
TL;DR: A wealth of evidence supports the view that the exchange of materials through the walls of living capillaries takes place by physical processes which involve no expenditure of energy on the part of the capillary endothelial cells themselves.
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Thermodynamics of hyperfiltration (reverse osmosis): criteria for efficient membranes
K.S. Spiegler,Ora Kedem +1 more