Journal ArticleDOI
Thermodynamic analysis of the permeability of biological membranes to non-electrolytes
Ora Kedem,Aharon Katchalsky +1 more
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TLDR
The equations derived here have been applied to various permeability measurements found in the literature, such as the penetration of heavy water into animal cells, permeability of blood vessels, threshold concentration of plasmolysis and relaxation experiments with artificial membranes.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1958-01-01. It has received 1960 citations till now. The article focuses on the topics: Membrane & Permeability (earth sciences).read more
Citations
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Journal ArticleDOI
The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat.
H. Ochsenfahrt,D. Winne +1 more
TL;DR: The high sieving coefficient for the two drugs at neutral pH is interpreted as indicating that water and lipophilic drug molecules interact within the lipid part of the cell membrane and at acidic pH the ionized drug molecules appear to permeate the cell membranes preferentially across other (presumably more hydrophilic) areas.
Book ChapterDOI
Calcium transport system: a comparative study in different cells.
TL;DR: This chapter summarizes the general aspects of the calcium transport system and the development of new methods of tissue fractionation for separation of plasma membrane fragments from intracellular organelles is significant.
Journal ArticleDOI
Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
Cynthia Hajal,Giovanni S. Offeddu,Yoo Kun Shin,Shun Zhang,Olga Morozova,Dean Hickman,Charles G. Knutson,Roger D. Kamm +7 more
TL;DR: In this paper , the authors describe an in vitro model of the human blood-brain barrier, self-assembled within microfluidic devices from stem-cell-derived or primary brain endothelial cells, and primary brain pericytes and astrocytes.
Journal ArticleDOI
Glucose and glycerol compared as osmotic agents for peritoneal dialysis
TL;DR: The observed increase in peritoneal permeability when glycerol was used resulted in a twofold increase in the caloric load imposed per unit of water removed in comparison with glucose.
Journal ArticleDOI
Sucrose fluxes and junctional water flow across Necturus gall bladder epithelium.
A. E. Hill,Bruria S. Hill +1 more
TL;DR: Most of the sucrose flow across the junctions must be convective in nature, and the size of the junctional water flow required amounts to most of the overall epithelial water flow, i.
References
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Journal ArticleDOI
Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability.
TL;DR: Theoretical and experimental studies on the sieving of molecules by ultrafiltration through porous membranes indicate that an effective pore diameter of at least IOO A would be required to explain permeability of this magnitude.
Journal ArticleDOI
Passage of Molecules Through Capillary Walls
TL;DR: A wealth of evidence supports the view that the exchange of materials through the walls of living capillaries takes place by physical processes which involve no expenditure of energy on the part of the capillary endothelial cells themselves.
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Thermodynamics of hyperfiltration (reverse osmosis): criteria for efficient membranes
K.S. Spiegler,Ora Kedem +1 more