Journal ArticleDOI
Thermodynamic analysis of the permeability of biological membranes to non-electrolytes
Ora Kedem,Aharon Katchalsky +1 more
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TLDR
The equations derived here have been applied to various permeability measurements found in the literature, such as the penetration of heavy water into animal cells, permeability of blood vessels, threshold concentration of plasmolysis and relaxation experiments with artificial membranes.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1958-01-01. It has received 1960 citations till now. The article focuses on the topics: Membrane & Permeability (earth sciences).read more
Citations
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Mathematical model of renal regulation of urea excretion.
TL;DR: Digital computer solutions of the model equations indicate that virtually all experimental observations pertaining to the regulation of Urea excretion can be explained by an increase in the solvent drag of urea from the cortical and medullary c.c.d.
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Platelet aggregation in flowing blood in vitro. I. Production by controlled ADP convective diffusion and quantification by videodensitometry
TL;DR: To quantify and to control the effects of flow and diffusion of adenosine diphosphate (ADP) on platelet adhesion and aggregation in whole blood, a blood flow chamber was designed and constructed which platelet aggregates form at and adhere to a specified, microscopic site on Cuprophan membrane.
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Ion-exchange membranes - Correlation between structure and function
TL;DR: In this paper, the authors make use of the theoretical framework of irreversible thermodynamics as first applied by Staverman1 to membrane systems, and as amplified by a number of other investigators, particularly Kedem and Katchalsky2.
Journal ArticleDOI
Mechanical behavior of multi-cellular spheroids under osmotic compression
Monika E. Dolega,Giuseppe Zurlo,M. Le Goff,M. Greda,Claude Verdier,Jean-François Joanny,Jean-François Joanny,Giovanni Cappello,Pierre Recho +8 more
TL;DR: In this article, the authors used multicellular spheroids, a composite material made of cells, extracellular matrix and permeating fluid, as a proxy of an avascular early state tumor.
References
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Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability.
TL;DR: Theoretical and experimental studies on the sieving of molecules by ultrafiltration through porous membranes indicate that an effective pore diameter of at least IOO A would be required to explain permeability of this magnitude.
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Passage of Molecules Through Capillary Walls
TL;DR: A wealth of evidence supports the view that the exchange of materials through the walls of living capillaries takes place by physical processes which involve no expenditure of energy on the part of the capillary endothelial cells themselves.
Related Papers (5)
Thermodynamics of hyperfiltration (reverse osmosis): criteria for efficient membranes
K.S. Spiegler,Ora Kedem +1 more