Journal ArticleDOI
Thermodynamic analysis of the permeability of biological membranes to non-electrolytes
Ora Kedem,Aharon Katchalsky +1 more
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TLDR
The equations derived here have been applied to various permeability measurements found in the literature, such as the penetration of heavy water into animal cells, permeability of blood vessels, threshold concentration of plasmolysis and relaxation experiments with artificial membranes.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1958-01-01. It has received 1960 citations till now. The article focuses on the topics: Membrane & Permeability (earth sciences).read more
Citations
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Gastrointestinal lymphatic absorption of peptides and proteins
Werner Rubas,George M. Grass +1 more
TL;DR: Conversion of a substance into a drug-polymer complex such as dextran or cyclodextran together with co-application of an absorption promoter (bifunctional system) has been shown to be feasible and suitable for lymphatic delivery.
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Fluid resuscitation in patients with increased vascular permeability.
TL;DR: Fluid therapy is a uniformly accepted, logical, and highly effective therapeutic intervention for the treatment of patients with reductions in circulating intravascular volume and the use of colloids and crystalloids in these disorders is addressed.
Journal ArticleDOI
Lipophilicity in trans-bilayer transport and subcellular pharmacokinetics
TL;DR: This review summarizes the present status of subcellular pharmacokinetics with emphasis on passive trans-bilayer transport, and mechanisms of transport are analyzed with respect to amphiphilicity and lipophilicity.
Journal ArticleDOI
Canine RBC osmotic tolerance and membrane permeability
TL;DR: The objective of this study was to determine the cryobiological characteristics of canine red blood cells (RBC), which included the hydraulic conductivity, permeability coefficients of common cryoprotectant agents (CPAs), the associated reflection coefficient, the activation energies of L(p) and P(s) and the osmotic tolerance limits.
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Permeability of water and polar solutes in lipid bilayers
TL;DR: The permeation theories of Fick, Henry and Kedem and Katchalsky should be adapted to introduce interfacial and elastic phenomena to formulate a broader formalism for permeation in lipid membranes.
References
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Journal ArticleDOI
Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability.
TL;DR: Theoretical and experimental studies on the sieving of molecules by ultrafiltration through porous membranes indicate that an effective pore diameter of at least IOO A would be required to explain permeability of this magnitude.
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Passage of Molecules Through Capillary Walls
TL;DR: A wealth of evidence supports the view that the exchange of materials through the walls of living capillaries takes place by physical processes which involve no expenditure of energy on the part of the capillary endothelial cells themselves.
Related Papers (5)
Thermodynamics of hyperfiltration (reverse osmosis): criteria for efficient membranes
K.S. Spiegler,Ora Kedem +1 more