Journal ArticleDOI
Thermodynamic analysis of the permeability of biological membranes to non-electrolytes
Ora Kedem,Aharon Katchalsky +1 more
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TLDR
The equations derived here have been applied to various permeability measurements found in the literature, such as the penetration of heavy water into animal cells, permeability of blood vessels, threshold concentration of plasmolysis and relaxation experiments with artificial membranes.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1958-01-01. It has received 1960 citations till now. The article focuses on the topics: Membrane & Permeability (earth sciences).read more
Citations
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Journal ArticleDOI
Reflection coefficients of dog lung endothelium to small hydrophilic solutes.
TL;DR: Transcapillary gradients of small hydrophilic solutes produce substantial osmotic effects for short times (seconds).
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A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells.
TL;DR: The data suggest that BAECs actively adapt to elevated transmural pressure by mobilizing ZO-1 to intercellular junctions via microtubules, and the structures of the TJ determine transport rates but do not define the selectivity of the monolayer to solutes (sigma).
Journal ArticleDOI
Multiphasic Finite Element Framework for Modeling Hydrated Mixtures With Multiple Neutral and Charged Solutes
TL;DR: This generalized finite element framework for multiphasic materials makes it possible to model the mechanoelectrochemical behavior of biological tissues and cells and sets the stage for the future analysis of reactive mixtures to account for growth and remodeling.
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Effect of indomethacin on glomerular permeability in the nephrotic syndrome
TL;DR: Indomethacin is introduced in the treatment of glomerulonephritis and demonstrated that the drug can reduce proteinuria in patients with the nephrotic syndrome and the effect has so far remained unexplained.
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Permeability of human oocytes to ethylene glycol and their survival and spindle configurations after slow cooling cryopreservation
L. De Santis,Giovanni Coticchio,S.J. Paynter,David F. Albertini,Karla J. Hutt,I. Cino,M. Iaccarino,A. Gambardella,Carlo Flamigni,Andrea Borini +9 more
TL;DR: The oocyte plasmalemma possesses limited permeability to EG and EG exposure causes considerable osmotic stress, however, post-thaw rates of survival and normal meiotic spindle organization may be preserved by protocols which are designed in order to minimize osmosis stress.
References
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Filtration, diffusion and molecular sieving through peripheral capillary membranes; a contribution to the pore theory of capillary permeability.
TL;DR: Theoretical and experimental studies on the sieving of molecules by ultrafiltration through porous membranes indicate that an effective pore diameter of at least IOO A would be required to explain permeability of this magnitude.
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Passage of Molecules Through Capillary Walls
TL;DR: A wealth of evidence supports the view that the exchange of materials through the walls of living capillaries takes place by physical processes which involve no expenditure of energy on the part of the capillary endothelial cells themselves.
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Thermodynamics of hyperfiltration (reverse osmosis): criteria for efficient membranes
K.S. Spiegler,Ora Kedem +1 more