Toll-like receptor signaling in neural plasticity and disease
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TLDR
Recently discovered and unexpected roles for TLRs in neuroplasticity are described, and the implications for future basic and translational research studies are described.About:
This article is published in Trends in Neurosciences.The article was published on 2011-05-01 and is currently open access. It has received 435 citations till now. The article focuses on the topics: Toll-like receptor & Neurogenesis.read more
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Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
Guo Yong Zhang,Juxue Li,Sudarshana Purkayastha,Yizhe Tang,Hai Zhang,Ye Ingrid Yin,Bo Li,Gang Liu,Dongsheng Cai +8 more
TL;DR: The hypothalamus has a programmatic role in ageing development via immune–neuroendocrine integration, and immune inhibition or GnRH restoration in the hypothalamus/brain represent two potential strategies for optimizing lifespan and combating ageing-related health problems.
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.
TL;DR: An overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health is provided.
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Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.
Jason Dang,Shashi Kant Tiwari,Gianluigi Lichinchi,Yue Qin,Veena S. Patil,Alexey Eroshkin,Tariq M. Rana +6 more
TL;DR: It is shown that a prototype strain of ZIKV, MR766, efficiently infects organoids and causes a decrease in overall organoid size that correlates with the kinetics of viral copy number.
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Epilepsy and brain inflammation.
TL;DR: The clinical observations in drug-resistant human epilepsies and the experimental findings in adult and immature rodents linking brain inflammation to the epileptic process in a causal and reciprocal manner are reported.
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Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation.
TL;DR: This review summarizes recent progress concerning the mechanisms underlying ICH-induced inflammation, and focuses on the inflammatory signaling pathways involved in microglial activation and TLR signaling, and explores potential therapeutic interventions by targeting the removal of hematoma components and inhibition ofTLR signaling.
References
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Journal ArticleDOI
Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
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Pathways towards and away from Alzheimer's disease
TL;DR: Rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies in Alzheimer's disease.
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Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Matam Vijay-Kumar,Jesse D. Aitken,Frederic A. Carvalho,Tyler C. Cullender,Simon M. Mwangi,Shanthi Srinivasan,Shanthi V. Sitaraman,Rob Knight,Ruth E. Ley,Andrew T. Gewirtz +9 more
TL;DR: Results support the emerging view that the gut microbiota contributes to metabolic disease and suggest that malfunction of the innate immune system may promote the development of metabolic syndrome.
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Immune modulation of learning, memory, neural plasticity and neurogenesis
Raz Yirmiya,Inbal Goshen +1 more
TL;DR: These effects are mediated by inflammation-induced neuronal hyper-excitability and adrenocortical stimulation, followed by reduced production of neurotrophins and other plasticity-related molecules, facilitating many forms of neuropathology associated with normal aging as well as neurodegenerative and neuropsychiatric diseases.