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Open AccessJournal ArticleDOI

Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation

Katia Perruccio, +12 more
- 15 Dec 2005 - 
- Vol. 106, Iss: 13, pp 4397-4406
TLDR
Large numbers of donor T-cell clones specific for Aspergillus or cytomegalovirus antigens were generated and identified clones potentially responsible for causing GvHD by screening them for cross-reactivity against recipient mononuclear cells.
About: 
This article is published in Blood.The article was published on 2005-12-15 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Transplantation & Hematopoietic stem cell transplantation.

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Citations
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Journal ArticleDOI

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.

Salomé LeibundGut-Landmann, +11 more
- 01 Jun 2007 - 
TL;DR: It is shown that dectin-1–Syk–CARD9 signaling induced DC maturation and the secretion of proinflammatory cytokines, including IL-6, tumor necrosis factor and IL-23, but little IL-12.
Journal ArticleDOI

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Mauro Di Ianni, +22 more
- 07 Apr 2011 - 
TL;DR: It is shown for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect.
Journal ArticleDOI

Aspergillus fumigatus and Aspergillosis in 2019

Jean-Paul Latgé, +1 more
- 18 Dec 2019 - 
TL;DR: The emergence of new concepts, such as nutritional immunity and the integration and rewiring of multiple fungal metabolic activities occurring during lung invasion, has helped to redefine the opportunistic pathogenesis of A. fumigatus.
Journal ArticleDOI

Activity of Broad-Spectrum T Cells as Treatment for AdV, EBV, CMV, BKV, and HHV6 Infections after HSCT

Anastasia Papadopoulou, +14 more
- 25 Jun 2014 - 
TL;DR: The feasibility and clinical utility of rapidly generated single-culture VSTs that recognize 12 immunogenic antigens from five viruses that frequently cause disease in immunocompromised patients are demonstrated.
Journal ArticleDOI

Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.

Tobias M. Hohl, +6 more
- 19 Nov 2009 - 
TL;DR: It is demonstrated that pulmonary CD4 T cell responses to inhaled spores require CCR2(+)Ly6C(hi) monocytes and their derivatives, revealing a compartmentally restricted function for these cells in adaptive respiratory immune responses.
References
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Journal ArticleDOI

A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk

Robert Gray
- 01 Jan 1988 - 
TL;DR: In this paper, a class of tests developed for comparing the cumulative incidence of a particular type of failure among different groups is presented. The tests are based on comparing weighted averages of the hazards of the subdistribution for the failure type of interest.
Journal Article

1994 Consensus Conference on Acute GVHD Grading.

Donna Przepiorka, +6 more
- 01 Jun 1995 - 
TL;DR: Reports of GVHD prevention trials should include an accurate description of the grading system used and should report actuarial rates of grades II-IV and III-IV GV HD corrected for graft failure and potential interventions for early relapse.
Journal ArticleDOI

Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

Loredana Ruggeri, +11 more
- 15 Mar 2002 - 
TL;DR: It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
Journal ArticleDOI

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

Mark E. Dudley, +18 more
- 25 Oct 2002 - 
TL;DR: The adoptive transfer of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen resulted in the persistent clonal repopulation of T cells in cancer patients, leading to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction.
Journal ArticleDOI

A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and a T-killer cell

John Paul Ridge, +3 more
- 04 Jun 1998 - 
TL;DR: It is found that the three cells need not meet simultaneously but that the helper cell can first engage and ‘condition’ the dendritic cell, which then becomes empowered to stimulate a killer cell.
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