Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation
Hynek Mergental,Hynek Mergental,M. T. P. R. Perera,Richard W. Laing,Paolo Muiesan,John Isaac,Amanda Smith,Barney Stephenson,Hentie Cilliers,Desley Neil,Stefan G. Hubscher,Simon C. Afford,Darius F. Mirza +12 more
TLDR
Viability assessment of high‐risk grafts using NMP‐L provides specific information on liver function and can permit their transplantation while minimizing the recipient risk of primary graft nonfunction, which may increase organ availability for LT.About:
This article is published in American Journal of Transplantation.The article was published on 2016-11-01 and is currently open access. It has received 257 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Book ChapterDOI
Machine perfusion for donor organ repair: from vision to everyday clinical practice
TL;DR: This chapter provides an overview of the current insights and application of machine perfusion technologies in liver transplantation and how they may potentially be developed further and applied to repair injured organs to improve their quality.
Journal ArticleDOI
Management of the critically ill liver failure patient: surpassing our limitations to reach transplantation.
TL;DR: In this paper, the authors review advances in donor organ management, tools for patient selection and highlight ICU management of liver transplant recipients in patients with liver failure and liver-related diseases.
Journal ArticleDOI
Prolonged (≥24 Hours) Normothermic (≥32 °C) Ex Vivo Organ Perfusion: Lessons From the Literature.
Lise Tchouta,Lise Tchouta,Fares Alghanem,Fares Alghanem,Alvaro Rojas-Pena,Robert H. Bartlett +5 more
TL;DR: By examining successful techniques and protocols used, this review outlines the essential elements of successful perfusion, limitations of current perfusion systems, and areas where further research in preservation science is required.
Journal ArticleDOI
The role of machine perfusion in liver xenotransplantation.
TL;DR: NMP can not only assist in the development of other novel technologies by providing a unique environment to safely study organ function and assess organ suitability but may also improve outcomes following hepatic xenotransplantation.
Journal ArticleDOI
Moving the Margins: Updates on the Renaissance in Machine Perfusion for Organ Transplantation
Cray V. Noah,Philipp Tratnig-Frankl,Philipp Tratnig-Frankl,Siavash Raigani,Siavash Raigani,Curtis L. Cetrulo,Curtis L. Cetrulo,Korkut Uygun,Korkut Uygun,Heidi Yeh +9 more
TL;DR: Ex vivo machine perfusion is transitioning from being dormant to indispensable in clinical organ transplantation, providing a platform for extended assessment, superior preservation, and targeted therapy, which can make marginal, previously declined organs a part of the donor pool.
References
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The Clavien-Dindo classification of surgical complications: five-year experience.
Pierre A. Clavien,Jeffrey Barkun,Michelle L. de Oliveira,Jean Nicolas Vauthey,Daniel Dindo,Richard D. Schulick,Eduardo de Santibañes,Juan Pekolj,Ksenija Slankamenac,Claudio Bassi,Rolf Graf,René Vonlanthen,Robert Padbury,John L. Cameron,Masatoshi Makuuchi +14 more
TL;DR: This 5-year evaluation provides strong evidence that the classification of complications is valid and applicable worldwide in many fields of surgery, and subjective, inaccurate, or confusing terms such as “minor or major” should be removed from the surgical literature.
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Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation
Cyril Moers,Jacqueline M. Smits,Mark-Hugo J. Maathuis,Juergen Treckmann,Frank Van Gelder,Bogdan P. Napieralski,Margitta van Kasterop-Kutz,Jaap J. Homan van der Heide,Jean-Paul Squifflet,Ernest van Heurn,Guenter R. Kirste,Axel Rahmel,Henri G. D. Leuvenink,Andreas Paul,Jacques Pirenne,Rutger J. Ploeg +15 more
TL;DR: Hypothermic machine perfusion was associated with a reduced risk of delayed graft function and improved graft survival in the first year after transplantation.
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Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
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UK health performance: findings of the Global Burden of Disease Study 2010
Christopher J L Murray,Michael Richards,John N Newton,Kevin A. Fenton,H. Ross Anderson,Charles Atkinson,Derrick A Bennett,Eduardo Bernabé,Hannah Blencowe,Rupert R A Bourne,Tasanee Braithwaite,Carol Brayne,Nigel Bruce,Traolach S. Brugha,Peter Burney,Mukesh Dherani,Helen Dolk,Karen Edmond,Majid Ezzati,Abraham D. Flaxman,Thomas D. Fleming,Greg Freedman,David Gunnell,Roderick J. Hay,Sally Hutchings,Summer Lockett Ohno,Rafael Lozano,Ronan A Lyons,Wagner Marcenes,Mohsen Naghavi,Charles R. Newton,Neil Pearce,Daniel Pope,Lesley Rushton,Joshua A. Salomon,Kenji Shibuya,Theo Vos,Haidong Wang,Hywel C Williams,Anthony D. Woolf,Alan D. Lopez,Adrian Davis +41 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) as mentioned in this paper examined the patterns of health loss in the UK, the leading preventable risks that explain some of these patterns, and how UK outcomes compare with a set of comparable countries in the European Union and elsewhere in 1990 and 2010.
Journal ArticleDOI
Addressing liver disease in the UK: A blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis
Roger Williams,Richard Aspinall,Mark A Bellis,Ginette Camps-Walsh,Matthew E. Cramp,Anil Dhawan,James Ferguson,Daniel M. Forton,Graham R. Foster,Sir Ian Gilmore,Matthew Hickman,Mark Hudson,Deirdre Kelly,Andrew Langford,Martin Lombard,Louise Longworth,Natasha K. Martin,Kieran Moriarty,Philip N. Newsome,John O'Grady,Rachel Pryke,Harry Rutter,Stephen D. Ryder,Nick Sheron,Thomas J. Smith +24 more
TL;DR: The aim of this Commission is to provide the strongest evidence base through involvement of experts from a wide cross-section of disciplines, making firm recommendations to reduce the unacceptable premature mortality and disease burden from avoidable causes and to improve the standard of care for patients with liver disease in hospital.
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