Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells.
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TLDR
Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells and animal studies show promising results in animals and humans.Abstract:
Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cellsread more
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Concise review: adipose tissue-derived stromal cells--basic and clinical implications for novel cell-based therapies.
TL;DR: Compared with bone marrow‐derived mesenchymal stem cells, adipose tissue‐derived stromal cells (ADSC) do have an equal potential to differentiate into cells and tissues of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, but the easy and repeatable access to subcutaneous adipOSE tissue and the simple isolation procedures provide a clear advantage.
Journal ArticleDOI
The potential of adipose stem cells in regenerative medicine.
TL;DR: The safety, reproducibility and quality of the stem cells must thoroughly be examined prior to extensive use in clinical applications, as cell therapies are becoming more frequent and the need for control in the processing laboratory grows consequently involving a greater risk of complications and possibly adverse events for the recipient.
Journal ArticleDOI
Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells.
Sarah Barlow,Gary Brooke,Konica Chatterjee,Gareth Price,Rebecca A. Pelekanos,Tony Rossetti,Marylou Doody,Deon J. Venter,Scott Pain,Kristen Gilshenan,Kerry Atkinson +10 more
TL;DR: It is suggested that human placenta is an acceptable alternative source for human MSC and their use is currently being evaluated in clinical trials.
Journal ArticleDOI
Immunomodulatory properties of human periodontal ligament stem cells
TL;DR: Results suggest that PDLSCs, BMSSCs, DPSCs, and GFs possess immunosuppressive properties mediated, in part, by soluble factors, produced by activated PBMNCs.
Journal ArticleDOI
Clinical applications of mesenchymal stem cells.
Na Youn Kim,Seok-Goo Cho +1 more
TL;DR: In the clinical setting, MSCs are being explored in trials of various conditions, including orthopedic injuries, graft versus host disease following bone marrow transplantation, cardiovascular diseases, autoimmune diseases, and liver diseases.
References
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Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex.
TL;DR: MSC added to PBL cultures had various effects, ranging from slight inhibition to stimulation of DNA synthesis, which was not affected by the MSC dose or by the addition of allogeneic or autologous MSCs to the lymphocytes.
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Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo.
TL;DR: Because ADAS cells can be expanded in culture without obvious senescence for more than 20 population doublings, they may be a potential source of endothelial cells for cellular pro-angiogenic therapies.
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Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia.
M. J. Pongers-Willemse,T Seriu,Stolz F,E D'Aniello,Gameiro P,Pisa P,Marcos González,C. R. Bartram,Panzer-Grümayer Er,Andrea Biondi,San Miguel Jf,van Dongen Jj +11 more
TL;DR: In this paper, the authors developed a set of PCR primers and protocols for the detection of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) using clone-specific junctional regions of immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets.
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Mesenchymal Stem Cells Inhibit the Expression of CD25 (Interleukin‐2 Receptor) and CD38 on Phytohaemagglutinin‐Activated Lymphocytes
K. Le Blanc,Ida Rasmusson,Cecilia Götherström,C Seidel,Berit Sundberg,Mikael Sundin,Kerstin Rosendahl,Charlotte Tammik,O Ringdén +8 more
TL;DR: Human MSC suppress proliferation of both CD4+ and CD8+ lymphocyte and decrease the expression of activation markers, when lymphocytes were activated in the presence of MSC.
Journal ArticleDOI
Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study
Hildegard Greinix,Beatrix Volc-Platzer,Peter Kalhs,Gottfried Fischer,A Rosenmayr,Felix Keil,Hubert Hönigsmann,Robert Knobler +7 more
TL;DR: The findings suggest that ECP is an effective adjunct therapy for acute steroid-refractory GVHD with cutaneous and liver involvement, however, in patients with acute GV HD grade IV or gut involvement other therapeutic options are warranted.