TTLL7 Is a Mammalian β-Tubulin Polyglutamylase Required for Growth of MAP2-positive Neurites
Koji Ikegami,Masahiro Mukai,Jun-ichi Tsuchida,Robb L. Heier,Grant R. MacGregor,Mitsutoshi Setou +5 more
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TLDR
Findings indicate that TTLL7 is a β-tubulin polyglutamylase and is required for the growth of MAP2-positive neurites in PC12 cells.About:
This article is published in Journal of Biological Chemistry.The article was published on 2006-10-13 and is currently open access. It has received 153 citations till now. The article focuses on the topics: Polyglutamylation & Tubulin.read more
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Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
TL;DR: Functional studies demonstrating that post-translational modifications may regulate microtubule functions through an amazing range of mechanisms are demonstrated.
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Tubulin modifications and their cellular functions
TL;DR: Recent studies demonstrating that tubulin modifications influence microtubule-associated proteins such as severing proteins, plus-end tracking proteins, and molecular motors play an important role in regulatingmicrotubule properties, such as stability and structure, as well as microtubules-based functions, suchAs ciliary beating, cell division, and intracellular trafficking.
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The tubulin code.
Kristen J. Verhey,Jacek Gaertig +1 more
TL;DR: Recent progress in understanding how the tubulin code is generated, maintained, and read by microtubule effectors is reviewed.
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The tubulin code: molecular components, readout mechanisms, and functions.
TL;DR: This work has shed light on how posttranslational modifications of tubulin could contribute to a “tubulin code” that coordinates the complex functions of microtubules in cells.
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The tubulin code and its role in controlling microtubule properties and functions.
TL;DR: This work discusses how tubulin isotypes and post-translational modifications control microtubule behaviour at the molecular level and how this translates into physiological functions at the cellular and organism levels, and shows how fine-tuning of microtubules function by some tubulin modifications can affect homeostasis.
References
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The distribution of tau in the mammalian central nervous system.
TL;DR: Observations indicate that tau may help define a subpopulation of microtubules that is restricted to axons, and the monoclonal antibody described in this report should prove very useful to investigators studying axonal sprouting and growth because it is an exclusive axonal marker.
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Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
Kumiko Ui-Tei,Yuki Naito,Fumitaka Takahashi,Takeshi Haraguchi,Hiroko Ohki-Hamazaki,Aya Juni,Ryu Ueda,Kaoru Saigo +7 more
TL;DR: The rules that may govern siRNA sequence preference are presented and in accordance with which highly effective siRNAs essential for systematic mammalian functional genomics can be readily designed.
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Altered microtubule organization in small-calibre axons of mice lacking tau protein
Akihiro Harada,Keiko Oguchi,Shigeo Okabe,Junko Kuno,Sumio Terada,T. Ohshima,Reiko Sato-Yoshitake,Yosuke Takei,Tetsuo Noda,Nobutaka Hirokawa +9 more
TL;DR: The results argue against the suggested role of tau in axonal elongation but confirm that it is crucial in the stabilization and organization of axonal microtubules in a certain type of axon.
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Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.
TL;DR: Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites, and this interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.
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Purification of brain tubulin through two cycles of polymerization-depolymerization in a high-molarity buffer
Mirco Castoldi,Andrei V. Popov +1 more
TL;DR: It is shown that only two cycles of polymerization-depolymerization of pig brain tubulin in the presence of a high-molarity PIPES buffer allow the efficient removal of contaminating proteins and production of ahigh-concentration tubulin solution.