Journal ArticleDOI
Valorization of industrial waste and by-product streams via fermentation for the production of chemicals and biopolymers
Apostolis A. Koutinas,Anestis Vlysidis,Daniel Pleissner,Nikolaos Kopsahelis,Isabel Lopez Garcia,Ioannis K. Kookos,Seraphim Papanikolaou,Tsz Him Kwan,Carol Sze Ki Lin +8 more
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TLDR
It is evident that fermentative production of chemicals and biopolymers via refining of waste and by-product streams is a highly important research area with significant prospects for industrial applications.Abstract:
The transition from a fossil fuel-based economy to a bio-based economy necessitates the exploitation of synergies, scientific innovations and breakthroughs, and step changes in the infrastructure of chemical industry. Sustainable production of chemicals and biopolymers should be dependent entirely on renewable carbon. White biotechnology could provide the necessary tools for the evolution of microbial bioconversion into a key unit operation in future biorefineries. Waste and by-product streams from existing industrial sectors (e.g., food industry, pulp and paper industry, biodiesel and bioethanol production) could be used as renewable resources for both biorefinery development and production of nutrient-complete fermentation feedstocks. This review focuses on the potential of utilizing waste and by-product streams from current industrial activities for the production of chemicals and biopolymers via microbial bioconversion. The first part of this review presents the current status and prospects on fermentative production of important platform chemicals (i.e., selected C2-C6 metabolic products and single cell oil) and biopolymers (i.e., polyhydroxyalkanoates and bacterial cellulose). In the second part, the qualitative and quantitative characteristics of waste and by-product streams from existing industrial sectors are presented. In the third part, the techno-economic aspects of bioconversion processes are critically reviewed. Four case studies showing the potential of case-specific waste and by-product streams for the production of succinic acid and polyhydroxyalkanoates are presented. It is evident that fermentative production of chemicals and biopolymers via refining of waste and by-product streams is a highly important research area with significant prospects for industrial applications.read more
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Journal ArticleDOI
Biotechnological approach to generate green biohydrogen through the utilization of succinate-rich fermentation wastewater
Muhammad Alif Fitri Hanipa,Peer Mohamed Abdul,Jamaliah Md Jahim,Mohd Sobri Takriff,Alissara Reungsang,Shu-Yii Wu +5 more
TL;DR: It was determined that acetate and succinate promoted the fastest growth of KKU-PS1 and hydrogen evolution, respectively, and highlighted potential of utilizing bio-succinate fermentation effluent for biohydrogen production, with further optimization required.
Journal ArticleDOI
Cellular Engineering and Biocatalysis Strategies toward Sustainable Cadaverine Production: State of the Art and Perspectives
TL;DR: Cadaverine, a diamine monomer, broadly exists in living organisms participating in metabolism processes and is a promising substitute of 1,6-diaminohexane as a substitute for dicarboxylic acid.
Journal ArticleDOI
Efficient production of polyhydroxybutyrate from slaughterhouse waste using a recombinant strain of Cupriavidus necator DSM 545.
TL;DR: In this paper, a recombinant lipolytic C. necator microbe was developed for the efficient conversion of slaughtering by-products into polyhydroxyalkanoates by accurately selected and developed bacterial strains.
Journal ArticleDOI
A simple and efficient model for calculating fixed capital investment and utilities consumption of large-scale biotransformation processes
TL;DR: A simple and accurate mathematical model is presented, which describes the economics of the bioreaction section of a typical biotransformation technology, and can be used to compare the economic performance of different bio-based technologies that could potentially reach commercialization.
Journal ArticleDOI
From microbial upcycling to biology-oriented synthesis: combining whole-cell production and chemo-enzymatic functionalization for sustainable taxanoid delivery
Max Hirte,Wolfgang Mischko,K. Kemper,S. Röhrer,Claudia Huber,Monika Fuchs,Wolfgang Eisenreich,Mirjana Minceva,Thomas Brück +8 more
TL;DR: A holistic bio-process based on the microbial upcycling of low-value feedstocks and leading to chemo-enzymatically derived, functionalized taxanoids was established, which is favorable under economic constraints and showed improved yields, reproducibility and transferability at any scale compared to inducible taxadiene production platforms examined in this study.
References
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Cellulose: Fascinating Biopolymer and Sustainable Raw Material
TL;DR: The current knowledge in the structure and chemistry of cellulose, and in the development of innovative cellulose esters and ethers for coatings, films, membranes, building materials, drilling techniques, pharmaceuticals, and foodstuffs are assembled.
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Technology development for the production of biobased products from biorefinery carbohydrates—the US Department of Energy’s “Top 10” revisited
TL;DR: An updated evaluation of potential target structures using similar selection methodology, and an overview of the technology developments that led to the inclusion of a given compound are presented.
Journal ArticleDOI
Recent trends in global production and utilization of bio-ethanol fuel
Mustafa Balat,Havva Balat +1 more
TL;DR: The most widely used bio-fuel for transportation worldwide is bio-ethanol from sugar cane, which is essentially a clean fuel and has several clear advantages over petroleum-derived gasoline in reducing greenhouse gas emissions and improving air quality in metropolitan areas as mentioned in this paper.
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Characterization and genomic analysis of kraft lignin biodegradation by the beta-proteobacterium Cupriavidus basilensis B-8
TL;DR: These results confirmed the capability of C. basilensis B-8 to promote KL degradation and provide a theoretical basis for research into the mechanisms of lignin degradation as well as a practical basis for biofuel production using lignIn materials.
Journal ArticleDOI
A review of the production of ethanol from softwood
Mats Galbe,Guido Zacchi +1 more
TL;DR: The current status of the technology for ethanol production from softwood is reviewed, with focus on hemicellulose and cellulose hydrolysis, which is the major problem in the overall process.