Journal ArticleDOI
Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1
Thomas C. Quinn,Maria J. Wawer,Nelson K. Sewankambo,David Serwadda,Chuanjun Li,Fred Wabwire-Mangen,Mary Meehan,Tom Lutalo,Ronald H. Gray +8 more
Reads0
Chats0
TLDR
The viral load is the chief predictor of the risk of heterosexual transmission of HIV-1, and transmission is rare among persons with levels of less than 1500 copies of HIV -1 RNA per milliliter.Abstract:
Background and Methods We examined the influence of viral load in relation to other risk factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In a community-based study of 15,127 persons in a rural district of Uganda, we identified 415 couples in which one partner was HIV-1–positive and one was initially HIV-1–negative and followed them prospectively for up to 30 months. The incidence of HIV-1 infection per 100 person-years among the initially seronegative partners was examined in relation to behavioral and biologic variables. Results The male partner was HIV-1–positive in 228 couples, and the female partner was HIV-1–positive in 187 couples. Ninety of the 415 initially HIV-1–negative partners seroconverted (incidence, 11.8 per 100 person-years). The rate of male-to-female transmission was not significantly different from the rate of female-to-male transmission (12.0 per 100 person-years vs. 11.6 per 100 person-years). The incidence of seroconversion was highest among ...read more
Citations
More filters
Journal ArticleDOI
Trends in Primary and Secondary Syphilis Among Men Who Have Sex with Men in the United States
TL;DR: Increasing syphilis cases among MSM account for most of the recent overall increase in rates and may be a harbinger of increasing rates of HIV infection among MSM.
Journal ArticleDOI
Response to the AIDS Pandemic — A Global Health Model
Peter Piot,Thomas C. Quinn +1 more
TL;DR: How HIV–AIDS has been transformed from a death sentence into a manageable illness is described and the need for continued and coordinated international efforts is outlined.
Journal ArticleDOI
From Directly Observed Therapy to Accompagnateurs: Enhancing AIDS Treatment Outcomes in Haiti and in Boston
TL;DR: A pilot project in rural Haiti introduced DOT-HAART (directly observed therapy with highly active antiretroviral therapy) for the care of patients with advanced acquired immune deficiency syndrome and a similar effort was launched in Boston for patients with drug-resistant HIV disease who had experienced failure of unsupervised therapy.
Journal ArticleDOI
HIV testing and counselling for migrant populations living in high-income countries: a systematic review
Debora Alvarez-del Arco,Debora Alvarez-del Arco,Susana Monge,Amaya Azcoaga,Isabel Río,Victoria Hernando,Cristina González,Belén Alejos,Belén Alejos,Ana Maria Caro,Santiago Pérez-Cachafeiro,Oriana Ramírez-Rubio,Francisco Bolumar,Teymur Noori,Julia del Amo,Julia del Amo +15 more
TL;DR: Migrants and ethnic minorities should be offered HIV testing, but the barriers highlighted in this review may deter programs from achieving the final goal, which is linking migrants and Ethnic minorities to HIV clinical care under the public health perspective.
Journal ArticleDOI
HIV binding, penetration, and primary infection in human cervicovaginal tissue
TL;DR: A continuum of complex interactions that occurs when natural sources of HIV infectivity are deposited onto mucosal surfaces in the female reproductive tract is highlighted.
References
More filters
Book
Statistical Methods in Cancer Research
TL;DR: Statistical methods in cancer research as mentioned in this paper, Statistical Methods in Cancer Research, Statistical methods in Cancer research, Statistical methods for cancer research, کتابخانه مرکزی دانشگاه علوم پزش
Journal ArticleDOI
Statistical methods in cancer research
Journal ArticleDOI
From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection.
TL;DR: It is suggested that timely provision of STD services can substantially reduce HIV incidence, but raise additional questions about the optimal way to target and implement these services to achieve the greatest effect on HIV transmission.
Book
The design and analysis of cohort studies
N. E. Breslow,N. E. Day +1 more
TL;DR: The scope ranges from an account of the elementary and descriptive approaches to cohort analysis to the fitting of regression models for incidence rates with general risk functions, and particular attention is given to the use of a case-control approach embedded in a cohort study.
Journal ArticleDOI
Sexual transmission of HIV
TL;DR: The epidemiology and biology of the host-related factors that affect the sexual transmission of HIV and the host susceptibility and infectiousness environment biologic agent are discussed.
Related Papers (5)
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
Ronald H. Gray,Godfrey Kigozi,David Serwadda,Frederick Makumbi,Stephen Watya,Fred Nalugoda,Noah Kiwanuka,Lawrence H. Moulton,Mohammad A Chaudhary,Michael Z. Chen,Nelson K. Sewankambo,Fred Wabwire-Mangen,Melanie C. Bacon,Carolyn Williams,Pius Opendi,Steven J. Reynolds,Steven J. Reynolds,Oliver Laeyendecker,Oliver Laeyendecker,Thomas C. Quinn,Thomas C. Quinn,Maria J. Wawer +21 more