Vitamin D and cardio-metabolic disease.

TLDR: This editorial highlights recent updates on studies that evaluate the role of vitamin D in cardio-metabolic diseases, with an emphasis on those studies published in Metabolism in the past two years, thereby extending upon on prior summaries for readers.

Abstract: There has been an explosion in the number of investigations focused on the role of vitamin D in metabolic and cardiovascular diseases. Accompanying this growth and concentration of scientific reports has come a significant degree of confusion and uncertainty. This is largely attributed to the fact that large-scale randomized studies to evaluate the impact of vitamin D interventions on metabolic outcomes are still few and insufficient. While many studies support the role of vitamin D therapy in reducing cardio-metabolic risk factors, others do not, and notable limitations exist in almost all studies reported to date. Until definitive well-designed prospective intervention studies are completed, we at Metabolism have remained committed to reporting the latest scientific findings by publishing novel original articles, and summary reviews and editorials, focused on this constantly evolving field. Our goal has been to serve as a platform for advancing and distributing scientific knowledge in this arena, and providing clarity and editorial interpretations on the most contemporary data available. In this regard, this editorial highlights recent updates on studies that evaluate the role of vitamin D in cardio-metabolic diseases, with an emphasis on those studies published in Metabolism in the past two years, thereby extending upon on our prior summaries for our readers. Notably, recent issues of Metabolism, including this current one, have published novel studies focused on the interactions between vitamin D and the renin-angiotensin system, adiposity, insulin sensitivity, and genetics.