Bryan Kestenbaum

TL;DR: In this article, a genome-wide association study of 25-hydroxyvitamin D concentrations in 33,996 individuals of European descent from 15 cohorts was conducted to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.

TL;DR: In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases.

TL;DR: The SUNLIGHT Consortium GWAS of serum 25-hydroxyvitamin D concentrations has identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, and CYP24A1) as mentioned in this paper.

TL;DR: Lower serum 25(OH)D concentration was associated with an increased risk of incident CHD events among participants who were white or Chinese but not black or Hispanic, and these results may not be broadly generalizable to other racial or ethnic groups.

TL;DR: Knowing associations of low 25-hydroxyvitamin D with major health outcomes may vary according to common genetic differences in the vitamin D receptor, as well as complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-Hydroxyv vitamin D.