Journal ArticleDOI
Vps15p regulates the distribution of cup-shaped organelles containing the major eisosome protein Pil1p to the extracellular fraction required for endocytosis of extracellular vesicles carrying metabolic enzymes.
TLDR
This work hypothesised that extracellular vesicles are internalised using novel mechanisms independent of clathrin‐mediated endocytosis, and Saccharomyces cerevisiae is a model system to study trafficking of small vesicle in response to changes in the environment.About:
This article is published in Biology of the Cell.The article was published on 2017-05-01. It has received 7 citations till now. The article focuses on the topics: Vesicle & Eisosome.read more
Citations
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Journal ArticleDOI
Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. Vol. 279 (2004) 22030–22038
TL;DR: In this article, it was shown that Pkh1p phosphorylates both proteins in vitro in a reaction that is only weakly regulated by sphingolipid long-chain bases (LCBs).
Journal ArticleDOI
Rasal2 suppresses breast cancer cell proliferation modulated by secretory autophagy
Xuan Wang,Xuzhi Yin,Yonghua Yang +2 more
TL;DR: Findings revealed a new mechanism of Rasal2 in the regulation of breast cancer cell proliferation via autophagy-exo-mediated pathway.
Journal ArticleDOI
Extracellular Vesicles in the Fungi Kingdom
TL;DR: Extracellular Vesicles (EVs) are membranous, rounded vesicles released by prokaryotic and eukaryotic cells in their normal and pathophysiological states as mentioned in this paper.
Journal ArticleDOI
Intracellular vesicle clusters are organelles that synthesize extracellular vesicle–associated cargo proteins in yeast
TL;DR: This work investigated whether cytoplasmic organelles—called intracellular vesicle clusters (IVCs)—serve as sites for the synthesis of proteins targeted for secretion as EV-associated proteins in budding yeast cells grown under steady-state low-glucose conditions and identified 377 IVC- associated proteins.
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What Is New? Recent Knowledge on Fungal Extracellular Vesicles
TL;DR: The recent literature on fungal EVs reinforces the perception that these compartments are involved in intercellular communication and may represent interesting targets for antifungal development and tools for the generation of fungal vaccines.
References
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Journal ArticleDOI
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Journal ArticleDOI
Exosomes: extracellular organelles important in intercellular communication.
TL;DR: This review focuses on various strategies for purifying exosomes and discusses their biophysical and biochemical properties, and an update on proteomic analysis of exosome from various cell types and body fluids is provided and host-cell specific proteomic signatures are discussed.
Journal ArticleDOI
Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.
TL;DR: Coimmunoprecipitation experiments showed that two distinct Vps34 PtdIns 3–kinase complexes exist: one, containing Vps15p, Vps30p, and Apg14p, functions in autophagy and the other containing VPS15 p, VPS30 p, and Vps38p functions in CPY sorting.
Journal ArticleDOI
Exosomes: proteomic insights and diagnostic potential
TL;DR: The exacerbated release of exosomes in tumor cells, as evidenced by their increased levels in blood during the late stage of a disease and their overexpression of certain tumor cell biomarkers, suggests an important role of exOSomes in diagnosis and biomarker studies.
Journal ArticleDOI
ExoCarta: A compendium of exosomal proteins and RNA.
TL;DR: A compendium for proteins and RNA molecules identified in exosomes, first of its kind and freely available to the scientific community through the web, is described and believed that this community resource will be of great biological importance for any future exosome analyses.
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