Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement.
Wen-Hsiang Chen,Xinrong Tao,Anurodh S. Agrawal,Abdullah Algaissi,Bi Hung Peng,Jeroen Pollet,Ulrich Strych,Maria Elena Bottazzi,Peter J. Hotez,Sara Lustigman,Lanying Du,Shibo Jiang,Chien Te K. Tseng +12 more
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TLDR
A formulation with a 1:25 ratio of RBD219-N1 to Alhydrogel® provided high neutralizing antibody titers, 100% protection with non-detectable viral loads with minimal or no eosinophilic pulmonary infiltrates, and this vaccine formulation is under consideration for further development against SARS-CoV and potentially other emerging and re-emerging beta-CoVs such as SARS -CoV-2.About:
This article is published in Vaccine.The article was published on 2020-11-03 and is currently open access. It has received 73 citations till now. The article focuses on the topics: Neutralizing antibody & Viral Vaccine.read more
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The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens.
TL;DR: This review highlights and describes the recent progress that has been made in the biosynthesis, structure, function, and antigenicity of the SARS-CoV-2 S glycoprotein, aiming to provide valuable insights into the design and development ofThe S protein-based vaccines as well as therapeutics.
Posted ContentDOI
Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding.
Tyler N. Starr,Allison J. Greaney,Allison J. Greaney,Sarah K Hilton,Sarah K Hilton,Katharine H.D. Crawford,Katharine H.D. Crawford,Mary Jane Navarro,John E. Bowen,M. Alejandra Tortorici,Alexandra C. Walls,David Veesler,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +14 more
TL;DR: An interactive visualization and open analysis pipeline is presented to facilitate use of the dataset for vaccine design and functional annotation of mutations observed during viral surveillance.
Journal ArticleDOI
Prospects for a safe COVID-19 vaccine.
Barton F. Haynes,Lawrence Corey,Prabhavathi Fernandes,Peter B. Gilbert,Peter J. Hotez,Srinivas S. Rao,Michael R. Santos,Hanneke Schuitemaker,Michael Watson,Ann M. Arvin +9 more
TL;DR: Evaluated research on the potential risk of immune enhancement of disease by vaccines and viral infections, including coronavirus infections, together with emerging data about COVID-19 disease finds neither principles of immunity nor preclinical studies provide a basis for prioritizing among the CO VID-19 vaccine candidates with respect to safety.
Journal ArticleDOI
SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants.
Daniel Martínez-Flores,Jesús Zepeda-Cervantes,Adolfo Cruz-Reséndiz,Sergio Aguirre-Sampieri,Alicia Sampieri,Luis Vaca +5 more
TL;DR: Wang et al. as mentioned in this paper reviewed the different types of vaccines designed and developed against SARS-CoV-2, placing emphasis on whether they are based on the complete S glycoprotein, its antigenic domains such as the receptor-binding domain (RBD) or short epitopes within the S gly coprotein.
Journal ArticleDOI
COVID-19 vaccine development: milestones, lessons and prospects
Maochen Li,Han Wang,Lili Tian,Zehan Pang,Qingkun Yang,Tianqi Huang,Junfen Fan,Lihua Song,Yigang Tong,Huahao Fan +9 more
TL;DR: In this article , the safety and efficacy of COVID-19 vaccines were evaluated, including the possible complications and different effects on pregnant women, the elderly, people with immune diseases and acquired immunodeficiency syndrome (AIDS), transplant recipients, and cancer patients.
References
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Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
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TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
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A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
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The spike protein of SARS-CoV — a target for vaccine and therapeutic development
TL;DR: Recent advances in the development of vaccines and therapeutics based on the S protein are highlighted, which plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
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Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003
Nanshan Zhong,Bo-Jian Zheng,Yimin Li,Leo L.M. Poon,Z. H. Xie,KH Chan,Philip H. Li,S. Y. Tan,Qingsong Chang,J. P. Xie,X. Q. Liu,J. Xu,D. X. Li,Kwok-Yung Yuen,Joseph S. M. Peiris,Yi Guan +15 more
TL;DR: Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world.
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