Showing papers on "Morpholine published in 1994"

Synthesis of SAPO-34: high silicon incorporation in the presence of morpholine as template

Abstract: Synthesis of small pore SAPO-34 molecular sieve has been achieved under optimum conditions, elucidated by a detailed study of the kinetics of crystallization, in the presence of morpholine as a template. Incorporation of high silicon content into the framework of SAPO-34 has been observed and corroborated by physico-chemical characterization studies. Magic-angle spinning (MAS) NMR investigation points to the existence of aluminosilicate domains in the SAPO framework.

Clear conditioning composition

Abstract: A method of imparting improved conditioning properties to hair comprising treating the hair with a clear conditioning composition comprising an amidoamine salt, said amidoamine salt comprising an amidoamine compound having the general structural formula: ##STR1## neutralized with a suitable acid, wherein R1 is a fatty acid chain having about 11 to about 21 carbon atoms, R2 is an alkylene group having two to about four carbon atoms, R3 is hydrogen, methyl, ethyl or a hydroxyalkylene group having one to about three carbon atoms, R4 is methyl, ethyl or a hydroxyalkylene group having one to about three carbon atoms, and Y is a heterocyclic nitrogen-containing moiety, like morpholine or pyridine; and a silicone compound having at least one quaternary ammonium moiety.

Effect of phosphate activating group on oligonucleotide formation on montmorillonite: the regioselective formation of 3',5'-linked oligoadenylates

Abstract: The effects of amine structure on the montmorillonite-catalyzed oligomerization of the 5'-phosphoramidates of adenosine are investigated. 4-Aminopyridine derivatives yielded oligoadenylates as long as dodecamers with a regioselectivity for 3',5'-phosphodiester bond formation averaging 88%. Linear and cyclic oligomers are obtained and no A5'ppA-containing products are detected. Oligomers as long as the hexanucleotide are obtained using 2-aminobenzimidazole as the activating group. A predominance of pA2'pA is detected in the dimer fraction along with cyclic 3',5'-trimer; no A5'ppA-containing oligomers were detected. Little or no oligomer formation was observed when morpholine, piperidine, pyrazole, 1,2,4-triazole, and 2-pyridone are used as phosphate-activating groups. The effects of the structure of the phosphate activating group on the oligomer structure and chain lengths are discussed.

Microcrystal structure determination of AlPO4-CHA using synchrotron radiation

Abstract: Data were recorded from a very small crystal of AlPO 4 -CHA [trialuminum morpholinium fluoride tris(phosphate), C 4 H 10 NO + .Al 3 (PO 4 ) 3 F - ] using synchrotron radiation. The aluminophosphate framework forms a three-dimensional network of channels in which F atoms form bridges between octahedral Al atoms. The N atom of the template (morpholine) is hydrogen bonded to framework O atoms

New cleavable surfactants derived from glucono-1,5-lactone

Abstract: New amido nonionic cleavable surfactants were synthesized in good yields by the acetalization of glucono-1,5-lactone with octanal, 2-octanone or 2-undecanone, followed by amidation with monoethanolamine, diethanolamine or morpholine. These compounds possessed good water solubilities. The compounds derived from 2-octanone showed higher critical micelle concentrations than the compounds from octanal. For the same hydrophobic chain, both the micelle-forming property and the ability to lower surface tension increased with the change in the terminal amide group in the order diethanolamide

Tetracyclic morpholine derivatives and their use or analgesics

Abstract: A compound represented by the formula wherein X is hydrogen or a substituent; R¹ is an optionally substituted hydrocarbon residue; R² and R³ are respectively hydrogen or a substituent; and ​ ----- ¯ shows a single bond or a double bond, or a pharmacologically acceptable acid addition salt thereof, has an analgesic action and is useful as a medicine.

Peptide compounds derived from boronic acid

Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: R1 denotes hydrogen, acyl, alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl or linear or branched C1 -C6 alkyl, substituted or unsubstituted, or R6 SO2 -- in which R6 denotes alkyl, naphthyl, phenyl, benzyl or morpholine, R2 denotes hydrogen or phenyl, substituted or unsubstituted benzyl, thienylmethyl, (pyridyl)methyl, diphenylmethyl, fluorenyl, naphthylmethyl, benzocyclobutyl, (dicyclopropylmethyl)methyl, indanyl or (C3 -C7 cycloalkyl)methyl, R'2 denotes hydrogen or else R2 and R'2 together denote C6 H5 --CH═, R3 denotes any one of the groups as defined in the description, each of R4 and R5 denotes hydrogen or alkyl, or ##STR2## forms a boronic ester of pinanediol, A denotes the following group: ##STR3## in which n and A2 are as defined in the description, and medicinal products containing the same are useful as thrombin inhibitors.

Morpholine derivatives as dopamine receptor subtype ligands

Abstract: A class of substituted morpholine derivatives of formula (I), wherein Y represents an optionally substituted bicyclid heteroaromatic ring system containing one or two nitrogen atoms, the ring system comprising a six-membered aromatic or heteroaromatic ring fused to a five- or six-membered heteroaromatic ring; and Z represents an optionally substituted arylalkyl, aryloxymethyl or arylalkoxymethyl group, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia.

Amino- and aminomethylcholesterol derivatives with fungicidal acitivity

Abstract: Among a series of aminocholesterol derivatives synthesized, 7-aminocholesterol is the strongest inhibitor of yeast cell growth. Using sterol auxotrophic mutant strains, we showed that this compound inhibits cell proliferation by interfering with ergosterol biosynthesis. The sterol pattern of treated cells revealed that 7-aminocholesterol inhibits delta 8-->delta 7-sterol isomerase and delta 14-sterol reductase as morpholine inhibitors. However, the novel feature of this compound is a strong cytotoxicity to yeast.

Kinetics of aminolysis of some benzoyl fluorides and benzoic anhydrides in non-hydroxylic solvents

Abstract: The kinetic form of the spontaneous aminolysis of benzoyl fluorides in non-hydroxylic solvents is unlike that reported for the other benzoyl halides but is similar to that found for the aminolysis of esters. Variations on the mechanisms currently advocated for ester aminolysis are suggested for the benzoyl fluoride reactions. Tetrahedral intermediates are likely, but their rate-determining breakdown to products may involve a simultaneous proton transfer to the leaving fluoride ion. The kinetic behaviour differs from that found for aqueous solutions. The kinetics of the spontaneous aminolysis of benzoic anhydrides by primary amines, and by morpholine, in dioxane solution are first-order in each reagent over a wide amine concentration range, but the aminolysis by imidazoles involves also an important kinetic term second-order in amine. The mechanistic implications are discussed. Again the observations differ from some of those reported for aqueous solutions. For aminolyses of a variety of acylating agents, kinetic observations using non-hydroxylic solvents show that the easier it is for the leaving group to depart, owing to the structure of the acylating agent and/or that of the attacking amine, the less important become paths involving two or more amine molecules, but that such paths are generally more important than they are in hydroxylic solvents.

2,3-Dihydrospiro[1H-4- and 5-azabenzimidazole-2,1′ -cyclohexane] ( = Spiro[cyclohexane-1,2′(3′H)-1′H-imidazo[4,5-b]pyridine] and Spiro[cyclohexane-1,2′(3′H)-1′H-imidazo[4, 5-c]pyridine]): Reactions with Nucleophiles

Abstract: The readily available title compounds 4a and 24 react with N-, O-, S-, and C-nucleophiles in presence of MnO2 to give the corresponding mono- or disubstituted 2H-azabenzimidazoles ( = azaisobenzimidazoles), e.g., 11–18 and 26a–h, respectively, or 2,3-dihydro-1H-azabenzimidazoles ( = dihydro-azabenzimidazoles) such as 9 and 10 and 27 and 28, respectively, by a 1, 4- or 1,6-Michael addition (Schemes 2 and 4). The bromo-dihydro-1H-azabenzimidazole 4b lost the Br-atom when treated with piperidine or morpholine yielding the corresponding disubstituted 2H-azabenzimidazole 21 (Scheme 3). Reductive ring opening of the substituted spiro compounds leads to mono- and disubstituted diaminopyridines which are intermediates for fused pyridine ring systems with substituents often not available by conventional routes and of potential pharmaceutical interest (see 32–37). E.g., starting from 4a, a three-step synthesis of the analgesic flupirtine maleate (= ethyl {2-amino-6-[(4-fluorobenzyl)amino]pyridin-3-yl}carbamate maleate = Katadolon®; 39) and of its non-fluorinated derivative D-7195 is described. Its analogue 40 was similarly made from the spiro compound 24.

Degradation of morpholine by Mycobacterium aurum MO1

Abstract: When Mycobacterium aurum MO1 was grown with morpholine, the release of ammonia into the supernatant was proportional to the disappearance of morpholine, showing that this compound was mineralized. ...

2-substituted morpholine and thiomorpholine derivatives as gaba-b antagonists

Abstract: Disclosed are compounds of Formula (I) wherein: Y represents -CO2H, -CO2R6, -C(O)NHR7, -SO2H, -SO3H, -SO3R6, -SO2NHR7, -C(O)-N(OH)-R8, or a group of formula (a), (b), (c), (d) or (e); or a pharmaceutically acceptable addition salt or solvate thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula (I). Further disclosed is a method for treating or preventing respiratory depression, epileptic seizures or other central nervous system disorders, and for enhancing cognitive performance, by administering an effective amount of a compound of Formula (I).

Protection and polymerization of functional monomers, 22. Synthesis of well-defined poly(4-vinylbenzoic acid) by means of anionic living polymerization of N-(4-vinylbenzoyl)-N′-methylpiperazine, followed by deprotection†

Abstract: Anionic polymerizations of N-(4-vinylbenzoyl)-N′-methylpiperazine (3a) and N-(4-vinylbenzoyl)morpholine (3b) were carried out in tetrahydrofuran at −78°C with oligo(α-methylstyryl)-dilithium, -disodium, and -dipotassium. The polymerizations of both 3a and 3b proceeded quantitatively to give stable living polymers having predicted molecular weights and narrow molecular weight distributions. Novel block copolymers, poly(3a)-block-polystyrene-block-poly(3a) and poly(3b)-block-polystyrene-block-poly(3b), were synthesized by using these living polymerization systems. Under acidic conditions (6 N HCl in 1,4-dioxane-water), quantitative hydrolysis of the amide linkage of the poly(3a) was achieved to give a well-defined poly(4-vinyl-benzoic acid).

Derivatives of cyclobexylamine and morpholine as volatile corrosion inbibitors

Abstract: Forty-nine products, based on cyclohexylamine and morpholine, were evaluated as volatile corrosion inhibitorsfor mild steel. Fifteen showed an effectiveness in excess of 900% and may qualify for commercial application.

Gas chromatographic determination of residual hydrazine and morpholine in boiler feed water and steam condensates

Abstract: Hydrazine, an oxygen scavenger in boiler water, was derivatised to the corresponding acetone azine and determined at the ng ml−1 level by gas chromatography. Morpholine, a corrosion inhibitor used in steam boilers, was estimated either directly (if >2.0 μg ml−1) or by quantitative preconcentration (0.1 ng – 2.0 μg ml−1). To obtain symmetrical peaks for these amines, the column packing was coated with KOH. Use of a nitrogen-specific detector improved accuracy of estimation of hydrazine and morpholine, giving a RSD of 1.9–3.6%. Chromatographic analysis of these amines in boiler feed water and steam condensate samples collected from boilers servicing a petroleum refinery is described. Environmental safety regulations calls for monitoring of hydrazine and the methods developed can easily be adapted for this purpose.

Benzoylbenzofurane derivatives for treatment of cardiac arrhythmia

Abstract: Compound having structure (I) wherein R = H, OH, NH2, SH, halide, alkyl, O-alkyl, acyl, O-acyl, aryl, O-aryl, substituted amine, or substituted thiol; Y = OR1 wherein R1 is a straight or branched chain alkyl or heteroalkyl having 1 to 8 carbon atoms, a substituted or unsubstituted aryl or heteroaryl; or (a) wherein R2 and R3 are independently selected from H, alkyl or heteroalkyl of 1 to 6 carbon atoms, or wherein N is part of a cyclic or heterocyclic group comprising morpholine, triazole, imidazole, pyrrolidine, piperidine, piperazine, pyrrole, dihydropyridine, aziridine, thiazolidine, thiazoline, thiadiazolidine, or thiadiazoline; and X is O, S, or NH; a derivative of said compound; or a salt of said compound useful for treatment of cardiac arrhythmias, especially useful in patients with congestive heart failure (CHF). A process for synthesizing the compound is also described.

Conversion of allyl alk-2-ynoates to alk-2-ynoic acids using morpholine and palladium(0)-bis(diphenylphosphino)alkane catalyst; synthesis of 2,2,3,3-tetradehydro PGE1

Abstract: Allyl alk-2-ynoates can be readily converted into alk-2-ynoic acids by the reaction with morpholine in the presence of a palladium-diphenylphosphinopropane catalyst, thus providing the chemical deprotection method of allyl ester of 2,2,3,3-tetradehydro PGE1.

Kinetics and mechanisms of reaction between carbon disulphide and morpholine in aqueous solutions

Abstract: The reaction in aqueous solutions between carbon disulphide and morpholine has been studied experimentally at 303 K using a conductimetric stopped-flow technique. The observed pseudo-first order rate constant does not vary linearly with amine concentration but follows the equation: k obs = k Am [R 2 NH] 2 + k w [R 2 NH] [H 2 O]. This equation is compatible both with (1) zwitterion intermediate and (2) single-step termolecular reaction mechanisms which were previously proposed for the corresponding reactions of CO 2 and COS. Values of rate constants k Am and k w at 303 K are also reported

Silver(I) Ion-Mediated Desulfurization-Condensation of Thiocarbonyl Compounds with Several Nucleophiles

Abstract: The desulfurization-condensation reaction was investigated in the presence of silver(I) salt for several kinds of thiocarbonyl compounds with nucleophiles. Such thiocarbonyl compounds as 4,4′-bis(dimethylamino)thiobenzophenone, ethylene trithiocarbonate, and N-(thiobenzoyl)morpholine react with malononitrile or other active methylene compounds in the presence of silver trifluoroacetate to afford the corresponding olefinic compounds together with silver sulfide. This reaction of thiocarbonyl compounds with some other nucleophiles, such as aniline derivatives and ethylene glycol, has also afforded imines and 1,3-dioxolane derivatives.

Reaction of ethyl N‐(6‐ethoxycarbonyl‐2‐methylthiothieno[2,3‐d]‐pyrimidin‐5‐yl) formimidate with alkyl‐ and arylhydrazines: Formation of modified thieno[2,3‐d]pyrimidines and thieno[2,3‐d:4,5‐d]dipyrimidin‐4‐ones

Abstract: The reaction of ethyl N-(6-ethoxycarbonyl-2-methyl-thiothieno[2,3-d]pyrimidin-5-yl)formimidate (1) with methyl-hydrazine, N,N′-dimethyl- and N,N′-diphenylhydrazines separately in refluxing ethanol resulted in hydrolysis of formimidate group to give ethyl 5-amino-2-methylthiothieno[2,3-d] pyrimidine-6-carboxylate (2). The reaction on 1 with methyl-hydrazine without solvent afforded ethyl 5-amino-2-(1-methyl-hydrazino)thieno[2,3-d]pyrimidine-6-carboxylate (3), which underwent hydrazone formation with p-nitrobenzaldehyde to give 4. Treatment of 1 with N,N-dimethylhydrazine afforded a mixture of 3-dimethylamino-7-methylthiothieno[2,3-d:4,5-d']dipyrimidin-4(3H)-one (5) and 2. Displacement of methylthio group in 5 with morpholine, piperidine and 4-methylpiperazine gave the corresponding 7-substituted derivatives 6a-c. The reaction of 1 with para-substituted phenylhydrazines resulted in the formation of 3-(p-substituted phenylamino)7-methylthiothieno[2,3-d:4,5-d']dipyrimidin-4 (3H)ones (7a-c).