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Alexander A. Maini
Researcher at University College London
Publications - 20
Citations - 868
Alexander A. Maini is an academic researcher from University College London. The author has contributed to research in topics: Serum albumin & Inflammation. The author has an hindex of 8, co-authored 17 publications receiving 586 citations. Previous affiliations of Alexander A. Maini include University College Hospital.
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Journal ArticleDOI
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.
Amit Patel,Yan Zhang,James N. Fullerton,Lies Boelen,Anthony Rongvaux,Alexander A. Maini,Bigley,Richard A. Flavell,Richard A. Flavell,Derek W. Gilroy,Becca Asquith,Derek C. Macallan,Derek C. Macallan,Simon Yona +13 more
TL;DR: It is demonstrated that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day, which is consistent with a model of sequential transition.
Journal ArticleDOI
Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation
Madhur P. Motwani,Frances Bennett,Paul C. Norris,Alexander A. Maini,Marc J. George,Justine Newson,Alice Henderson,Adrian J. Hobbs,Mark Tepper,Barbara White,Charles N. Serhan,Raymond J. MacAllister,Derek W. Gilroy +12 more
TL;DR: A striking anti‐inflammatory and pro‐resolution effects of a synthetic analog of THC in healthy humans are demonstrated for the first time.
Journal ArticleDOI
Albumin Counteracts Immune-Suppressive Effects of Lipid Mediators in Patients With Advanced Liver Disease
Louise China,Alexander A. Maini,Simon S. Skene,Zainib Shabir,Yvonne Sylvestre,Romain A. Colas,Lucy Ly,Natalia Becares Salles,Vittorio Belloti,Jesmond Dalli,Derek W. Gilroy,Alastair O'Brien +11 more
TL;DR: Analysis of blood samples from patients with AD/ACLF participating in a feasibility study of 20% HAS infusions has shown that infusions to raise serum albumin above 30 g/L reversed plasma‐mediated immune dysfunction by binding and inactivating PGE2.
Journal ArticleDOI
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils
Baptiste Janela,Amit Patel,Mai Chan Lau,Chi Ching Goh,Rasha Msallam,Wan Ting Kong,Michael G. Fehlings,Sandra Hubert,Josephine Lum,Yannick Simoni,Benoit Malleret,Benoit Malleret,Francesca Zolezzi,Francesca Zolezzi,Jinmiao Chen,Michael Poidinger,Ansuman T. Satpathy,Carlos G. Briseño,Christian Wohn,Bernard Malissen,Kenneth M. Murphy,Alexander A. Maini,Leen Vanhoutte,Martin Guilliams,Emmanuel Vial,Laurent F. Hennequin,Evan W. Newell,Lai Guan Ng,Philippe Musette,Simon Yona,Feriel Hacini-Rachinel,Florent Ginhoux +31 more
TL;DR: Skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation as well as in a model of bacterial insult in human skin.
Journal ArticleDOI
Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation.
TL;DR: Despite limitations in scope and generalizability, human IV endotoxin challenge offers a unique platform to gain mechanistic insights into inducible physiological responses and inflammatory pathways, and may aid translation of this knowledge into therapeutic innovations.