Alicja Piechocka-Trocha

TL;DR: Differences in binding to viral peptide antigens by HLA may be the major factors underlying genetic differences between HIV controllers and progressors, and genome-wide association results implicate the nature of the HLA–viral peptide interaction as the major factor modulating durable control of HIV infection.

TL;DR: It is shown that PD-1 coordinately upregulates a program of genes in exhausted CD8+ T cells from humans and mice that includes upregulation of basic leucine transcription factor, ATF-like (BATF), a transcription factor in the AP-1 family that inhibit T cell function.

TL;DR: Factors that contribute to the immunogenicity of these highly targeted and relatively conserved sequences in HIV that may represent promising vaccine candidates for ethnically heterogeneous populations are identified.

TL;DR: The data demonstrate that HIV-specific CD4 T cell responses can be used during the earliest phase of HIV infection as an immunological predictor of subsequent viral set point and disease outcome and suggest that expansion of granzyme A+ HIV- specific cytolytic CD4T cell responses early during acute HIV infection contributes substantially to the control of viral replication.

TL;DR: The efficacy of such so-called 'protective alleles' is modulated by specific TCR clonotypes selected during natural infection, which provides a functional explanation for divergent HIV-1 outcomes.