자연주의적 탐구조사(Naturalistic Inquiry)

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Using Multivariate Statistics

Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

Data Mining Practical Machine Learning Tools and Techniques

Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S2

The goals of the …

/pdf/2013-acc-aha-guideline-on-the-treatment-of-blood-cholesterol-pvngcav7fq.pdf

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Recommendations and Strategies for IRP Truck Licensing Impacts for Ohio Counties

We report a 23-year-old man with relapsing encephalopathy with cerebellar ataxia (RECA) secondary to a mutation in ATP1A3 , characterized by fever related exacerbations associated with elevated CSF neopterin, and possible response to immunotherapy. This raises the possibility of an in ﬂ ammatory component to acute neurological deteriorations in ATP1A3 -related disease and has potential therapeutic implications.

ATP1A3‐Related Relapsing Encephalopathy with Cerebellar Ataxia (RECA): A Genetic Disorder with an Inflammatory Basis?

Dr Chris Barnes Dr Julie Curtin Dr Simon Brown Dr Ram Suppiah Dr Jamie Price Dr Susan Russell Dr Ritam Prasad Dr Michael Seldon Haematology, Royal Children’s Hospital, Melbourne, Victoria, Haematology, Children’s Hospital at Westmead, Sydney Children’s Hospital, Sydney, Haematology, Calvary Mater Hospital, Newcastle, New South Wales, Haematology, Royal Children’s Hospital, Brisbane, Queensland, Neonatology, Women’s and Children’s Hospital, Adelaide, South Australia, Haematology, Princess Margaret Hospital, Perth, Western Australia Haematology, Royal Hobart Hospital, Hobart, Tasmania, Australia

https://www.onlinelibrary.wiley.com/doi/pdf/10.1111/jpc.12591

A normal renal ultrasound scan excludes major abnormalities on dimercaptosuccinic acid in children with urinary tract infections.

This investigation comprised two studies that sought to identify the role of COVID-related disruptions in Australian university students’ academic motivation and engagement. Study 1 involved a dataset of 500 university students and examined the links between COVID-19 pandemic disruptions (remote and hybrid learning modes, lockdown, isolation) and students’ adaptive (e.g., planning and monitoring) and maladaptive (e.g., disengagement) dimensions of the Motivation and Engagement Scale (MES). Study 2 compared the mean motivation and engagement of Study 1 participants with mean levels from four published pre-COVID-19 Australian studies (N = 55, N = 233, N = 420, N = 941 university students) that also used the MES. Study 1 showed that lockdown and isolation (and not remote/hybrid learning) were associated with problematic motivation and engagement—with lockdown and isolation effects particularly noteworthy for maladaptive motivation and engagement. Study 2 showed that relative to the four pre-COVID-19 samples, the COVID-19 pandemic sample experienced difficulties with motivation and engagement, and again particularly so on maladaptive dimensions.

https://journals.sagepub.com/doi/pdf/10.1177/00049441231179791

University Students’ Motivation and Engagement During the COVID-19 Pandemic: The Roles of Lockdown, Isolation, and Remote and Hybrid Learning


 Thymic epithelial cells (TEC) are a heterogeneous population of stromal cells which orchestrate T cell development and selection. Although recent reports highlighted TEC complexity, their developmental origin, hierarchy and differentiation still remain ill-defined. We compared TEC distribution and gene expression in wild-type (WT) mice and in mice carrying Rag1 hypomorphic mutations (Rag1mut) observed in patients with immunedeficiency and immune dysregulation. Single cell RNA-seq analysis of TECs isolated from Rag1mut mice revealed an excess of cortical TECs (cTECs). Medullary TECs (mTECs), albeit reduced in number, showed a similar distribution in previously described mature subsets. To address whether TEC abnormalities in Rag1mut mice might result from a developmental block, we compared them to TECs from neonate WT mice. Indeed, we observed a similar TEC distribution in adult Rag1mut mice and newborn WT mice, although we identified peculiar features in cTEC subsets of Rag1mut mice. Transplantation of WT hematopoietic stem cells (HSC) into Rag1mut mice was able not only to correct thymocyte development, but also to revert TEC phenotype to normalcy. However, in a competitive transplantation setting where 10% of WT and 90% mutant HSCs were used, only partial restoration of thymocyte subsets was observed, associated with incomplete rescue of TEC phenotype. In summary, we show that abnormalities of TEC composition in Rag1 mutant mice correlate with impaired development of thymocytes, highlighting the role of lymphostromal cross-talk in TEC maturation. Moreover, these data point to the need to achieve full donor chimerism after HSC transplantation in order to rescue the thymic compartment and prevent defects of immune tolerance.
 This research was supported by the Intramural Research Program of the NIAID, NIH

Andrew J. Martin

Papers

Recommendations and Strategies for IRP Truck Licensing Impacts for Ohio Counties

ATP1A3‐Related Relapsing Encephalopathy with Cerebellar Ataxia (RECA): A Genetic Disorder with an Inflammatory Basis?

A normal renal ultrasound scan excludes major abnormalities on dimercaptosuccinic acid in children with urinary tract infections.

University Students’ Motivation and Engagement During the COVID-19 Pandemic: The Roles of Lockdown, Isolation, and Remote and Hybrid Learning

Profound abnormalities in thymic epithelial cells in Rag1 hypomorphic mice: implications for immune reconstitution after stem cell transplantation