A
Anna Spada
Researcher at University of Milan
Publications - 326
Citations - 13577
Anna Spada is an academic researcher from University of Milan. The author has contributed to research in topics: Pituitary tumors & Acromegaly. The author has an hindex of 60, co-authored 322 publications receiving 12683 citations. Previous affiliations of Anna Spada include Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
Papers
More filters
Journal ArticleDOI
GTPase inhibiting mutations activate the α chain of G s and stimulate adenylyl cyclase in human pituitary tumours
TL;DR: A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein α chain, αs, which results in the activation of adenylyl cyclase, which bypasses the cells' normal requirement for trophic hormone.
Journal ArticleDOI
Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas.
TL;DR: A profoundly altered Gs protein is found in a group of human growth hormone-secreting pituitary adenomas, characterized by high secretory activity and intracellular cyclic AMP levels.
Journal ArticleDOI
Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line AIP Mutations and Pituitary Adenomas: An International Collaborative Study
Adrian Daly,Maria A. Tichomirowa,Patrick Petrossians,Elina Heliövaara,Marie Lise Jaffrain-Rea,Anne Barlier,Luciana Ansaneli Naves,Tapani Ebeling,Auli Karhu,Antti Raappana,Laure Cazabat,Ernesto De Menis,Carmen Fajardo Montañana,Gérald Raverot,Robert J. Weil,Timo Sane,Dominique Maiter,Sebastian J C M M Neggers,Maria Yaneva,AntoineAntoine Tabarin,Elisa Verrua,Eija Eloranta,Arnaud Murat,Outi Vierimaa,Pasi I. Salmela,Philippe Emy,Rodrigo A. Toledo,Maria Isabel Sabaté,Chiara Villa,Chiara Villa,Marc Popelier,Roberto Salvatori,Juliet Jennings,Ángel Ferrández Longás,José Ignacio Labarta Aizpún,Marianthi Georgitsi,Ralf Paschke,Cristina L. Ronchi,Matti Välimäki,Carola Saloranta,Wouter W. de Herder,Renato Cozzi,Mirtha Guitelman,Flavia Magri,Maria Stefania Lagonigro,Georges Halaby,Vinciane Corman,Marie-Thérèse Hagelstein,Jean-Francis Vanbellinghen,Gustavo Barcelos Barra,Anne-Paule Gimenez-Roqueplo,Fergus J. Cameron,Françoise Borson-Chazot,Ian M. Holdaway,Sergio P. A. Toledo,Günter K. Stalla,Anna Spada,Sabina Zacharieva,Jérôme Bertherat,Thierry Brue,Vincent Bours,Philippe Chanson,Lauri A. Aaltonen,Albert Beckers +63 more
TL;DR: Prisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility.
Journal ArticleDOI
Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas
TL;DR: It is reported here that in homogenates of human PRL adenomas, in which dopaminergic agonists act as inhibitors of PRL secretion, basal adenylate cyclase is inhibited by DA and the DA receptors mediating this inhibition have the same pharmacological properties as those regulatingPRL secretion.
Journal ArticleDOI
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase
Anna Spada,Maura Arosio,D. Bochicchio,Nicoletta Bazzoni,Lucia Vallar,Monique Bassetti,Giovanni Faglia +6 more
TL;DR: The results suggest that patients with constitutively active adenylyl cyclase have hyperactive tumors; the sensitivity of these tumors to inhibitory agents (somatostatin and dopamine), possibly counteracting the expression of activating mutations, might explain the low rate of tumor growth.