Brad H. Nelson

TL;DR: This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015 and aims to reduce incidence and improve outcomes for women with this disease.

TL;DR: The discovery that IL-2 is critical for the development and peripheral expansion of CD4+CD25+ regulatory T cells, which promote self-tolerance by suppressing T cell responses in vivo, prompts a re-evaluation of how best to clinically manipulate this important immunoregulatory pathway.

TL;DR: For 515 patients from six tumor sites, RNA-seq data from The Cancer Genome Atlas was used to identify mutations that were predicted to be immunogenic in that they yielded mutational epitopes presented by the MHC proteins encoded by each patient's autologous HLA-A alleles that were associated with increased patient survival.

TL;DR: Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.

TL;DR: In part because IL-2 was first identified as a T-cell growth factor, the major focus of investigation in IL-R2 signaling has been on the mechanism of mitogenic effects in cultured cell lines and the apparent functional redundancy of the A and H regions of IL- 2R beta, and their corresponding downstream pathways, with respect to the proliferative response.