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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Patent
Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids
TL;DR: In this article, the authors present methods for identifying, assessing, preventing, and treating metabolic disorders and modulating metabolic processes using PM20D1 and N- lipidated amino acids.
Patent
Compositions et procédés pour induire la différenciation du tissu adipeux brun
TL;DR: In this article, the authors present an invention concerne des procedes et des compositions permettant d'indire la differenciation des adipocytes bruns via modulation de lactivite et/ou de l'expression des deux proteines Prdmlβ and C/EBPβ.
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RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1α
Phillip A. Dumesic,Sarah E. Wilensky,Symanthika Bose,Jonathan G. Van Vranken,Steven P. Gygi,Bruce M. Spiegelman +5 more
TL;DR: In this paper , the RNA-binding protein RBM43 was found to suppress mitochondrial and thermogenic gene expression in a PGC1α-dependent manner and its loss protected cells from cytokine-induced mitochondrial impairment.
Patent
PGC-1β, PGC-1 homologue and uses therefor
TL;DR: In this paper, isolated nucleic acid molecules, designated PGC-1β nucleic acids molecules, which encode novel PGC 1 related coactivator molecules were provided, and diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
Patent
Methods for preventing and/or treating bone loss conditions by modulating irisin
TL;DR: In this article, the authors present methods of preventing and/or treating a subject afflicted with bone loss conditions comprising administering to the subject a therapeutically effective amount of an agent that decreases the amount and or activity of irisin.