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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
Marco Sandri,Jiandie D. Lin,Christoph Handschin,Wenli Yang,Zoltan Arany,Stewart H. Lecker,Alfred L. Goldberg,Bruce M. Spiegelman +7 more
TL;DR: The high levels of P GC-1α in dark and exercising muscles can explain their resistance to atrophy, and the rapid fall in PGC-1 α during atrophy should enhance the FoxO-dependent loss of muscle mass.
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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Christiane D. Wrann,James P. White,John Salogiannnis,Dina Laznik-Bogoslavski,Jun Wu,Di Ma,Jiandie D. Lin,Michael E. Greenberg,Bruce M. Spiegelman +8 more
TL;DR: It is shown that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance exercise in the hippocampus of mice.
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Terminal Differentiation of Human Breast Cancer through PPARγ
Elisabetta Mueller,Pasha Sarraf,Peter Tontonoz,Peter Tontonoz,Ronald M. Evans,Ronald M. Evans,Katherine J. Martin,Ming Zhang,Christopher D.M. Fletcher,Christopher D.M. Fletcher,Samuel Singer,Samuel Singer,Bruce M. Spiegelman +12 more
TL;DR: The data suggest that the PPAR gamma transcriptional pathway can induce terminal differentiation of malignant breast epithelial cells and thus may provide a novel, nontoxic therapy for human breast cancer.
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Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
TL;DR: It is demonstrated that TNF-alpha participates in obesity-related systemic insulin resistance by inhibiting the IR tyrosine kinase in the two tissues mainly responsible for insulin-stimulated glucose uptake: muscle and fat.
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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
Jae Bum Kim,Pasha Sarraf,Margaret E. Wright,Kwok M. Yao,Elisabetta Mueller,Gemma Solanes,Bradford B. Lowell,Bruce M. Spiegelman +7 more
TL;DR: This paper showed that gene expression in adipose tissue for adipocyte determination differentiation dependent factor (ADD) 1/sterol regulatory element binding protein (SREBP) 1 is reduced dramatically upon fasting and elevated upon refeeding; this parallels closely the regulation of two adipose cell genes that are crucial in energy homeostasis, fatty acid synthetase (FAS) and leptin.