B
Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
Papers
More filters
Journal ArticleDOI
miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling
Xiaojun Liu,Junjie Xiao,Han Zhu,Xin Wei,Colin Platt,Federico Damilano,Chunyang Xiao,Vassilios J. Bezzerides,Vassilios J. Bezzerides,Pontus Boström,Lin Che,Chunxiang Zhang,Bruce M. Spiegelman,Anthony Rosenzweig,Anthony Rosenzweig +14 more
TL;DR: In this article, microRNA-222 (miR-222) was upregulated in two distinct models of exercise and found that it was sufficient to protect the heart against adverse remodeling.
Journal ArticleDOI
Adipsin is an Adipokine that Improves β Cell Function in Diabetes
James C. Lo,James C. Lo,Sanda Ljubicic,Barbara Leibiger,Matthias Kern,Ingo B. Leibiger,Tilo Moede,Molly E. Kelly,Diti Chatterjee Bhowmick,Incoronata Murano,Paul Cohen,Paul Cohen,Alexander S. Banks,Melin J. Khandekar,Arne Dietrich,Jeffrey S. Flier,Saverio Cinti,Matthias Blüher,Nika N. Danial,Per Olof Berggren,Bruce M. Spiegelman +20 more
TL;DR: Findings indicate that the adipsin/C3a pathway connects adipocyte function to β cell physiology, and manipulation of this molecular switch may serve as a therapy in T2DM.
Journal ArticleDOI
APC-dependent suppression of colon carcinogenesis by PPARγ
Geoffrey D. Girnun,Wendy M. Smith,Stavit Drori,Pasha Sarraf,Elisabetta Mueller,Charis Eng,Prashant R. Nambiar,Daniel W. Rosenberg,Roderick T. Bronson,Winfried Edelmann,Raju Kucherlapati,Frank J. Gonzalez,Bruce M. Spiegelman +12 more
TL;DR: PPARγ can suppress β-catenin levels and colon carcinogenesis but only before damage to the APC/β- catenin pathway, suggesting a potentially important use for PPARγ ligands as chemopreventative agents in colon cancer.
Journal ArticleDOI
Adipsin and an endogenous pathway of complement from adipose cells.
TL;DR: The results indicate that complement activation occurs in a localized site, adipose tissue, in normal mice and is impaired in a state of metabolic dysfunction, which suggests a novel function for the proximal portion of this complement pathway related to adipose cell biology or energy balance.
Journal ArticleDOI
TNF-alpha and insulin resistance: summary and future prospects.
TL;DR: This review of evidence indicates that the cytokine tumor necrosis factor a (TNF-α) is an important player in the state of insulin resistance observed during obesity and how TNF- α interferes with insulin signaling is summarized.