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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Expression
Jennifer L. Estall,Mario Kahn,Marcus P. Cooper,ffolliott M. Fisher,Michele K. Wu,Dina Laznik,Lishu Qu,David E. Cohen,Gerald I. Shulman,Bruce M. Spiegelman +9 more
TL;DR: Hepatic gain of function and complete genetic ablation of PGC-1α show that this coactivator is important for activating the programs of gluconeogenesis, fatty acid oxidation, oxidative phosphorylation, and lipid secretion during times of nutrient deprivation.
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PPARγ in Monocytes: Less Pain, Any Gain?
TL;DR: These papers represent intriguing data obtained from isolated monocytic cells and the application of selective PPARγ agonists to animal models of inflammation and atherosclerosis should shed light on the ability of this receptor to modulate these important biological effects.
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NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.
Nikolaos Volakakis,Banafsheh Kadkhodaei,Eliza Joodmardi,Karin Wallis,Lia Panman,Jessica M. Silvaggi,Bruce M. Spiegelman,Thomas Perlmann +7 more
TL;DR: It is demonstrated that NR4A and the transcriptional coactivator PGC-1α independently regulate distinct CREB-dependent neuroprotective gene programs and are identified as essential mediators of neuroprotection after exposure to neuropathological stress.
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UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
Lawrence Kazak,Edward T. Chouchani,Irina G. Stavrovskaya,Gina Z. Lu,Mark P. Jedrychowski,Daniel F. Egan,Manju Kumari,Manju Kumari,Xingxing Kong,Xingxing Kong,Brian K. Erickson,John Szpyt,Evan D. Rosen,Evan D. Rosen,Michael P. Murphy,Bruce S. Kristal,Bruce S. Kristal,Steven P. Gygi,Bruce M. Spiegelman +18 more
TL;DR: It is found that in mice genetically lacking UCP1, cold-induced activation of metabolism triggers innate immune signaling and markers of cell death in BAT, and global proteomic analysis reveals that this cascade induced by U CP1 deletion is associated with a dramatic reduction in electron transport chain abundance.
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PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
Kyle A. Rasbach,Rana K. Gupta,Jorge L. Ruas,Jun Wu,Elnaz Naseri,Jennifer L. Estall,Bruce M. Spiegelman +6 more
TL;DR: A qPCR-based screen of all known transcriptional components to identify transcription factors that are quantitatively regulated by PGC-1α in cultured skeletal muscle cells identified hypoxia-inducible factor 2 α (HIF2α) as a major P GC-1 α target in skeletal muscle that is positively regulated by both exercise and β-adrenergic signaling.